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    TBCEL tubulin folding cofactor E like [ Homo sapiens (human) ]

    Gene ID: 219899, updated on 28-Oct-2024

    Summary

    Official Symbol
    TBCELprovided by HGNC
    Official Full Name
    tubulin folding cofactor E likeprovided by HGNC
    Primary source
    HGNC:HGNC:28115
    See related
    Ensembl:ENSG00000154114 MIM:610451; AllianceGenome:HGNC:28115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    El; LRRC35
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.9), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TBCEL in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (121024102..121090776)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (121047848..121114522)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120894811..120961485)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene uncharacterized LOC101929208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120826209-120826709 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120829234-120829455 Neighboring gene high mobility group box 1 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3999 Neighboring gene TBCEL-TECTA readthrough Neighboring gene HNF4 motif-containing MPRA enhancer 256 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:121000154-121001353 Neighboring gene tectorin alpha Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:121083583-121084082 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121106857-121107396 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121107397-121107936 Neighboring gene uncharacterized LOC105369533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121107937-121108476 Neighboring gene TRPC6 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough TBCEL-TECTA

    Readthrough gene: TBCEL-TECTA, Included gene: TECTA

    Clone Names

    • FLJ14177, MGC10233

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tubulin-specific chaperone cofactor E-like protein
    Names
    E-like
    catastrophin
    leucine rich repeat containing 35
    leucine-rich repeat-containing protein 35
    tubulin-specific chaperone e-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130047.3NP_001123519.1  tubulin-specific chaperone cofactor E-like protein

      See identical proteins and their annotated locations for NP_001123519.1

      Status: VALIDATED

      Source sequence(s)
      AP000646, AP001929
      Consensus CDS
      CCDS31692.1
      UniProtKB/Swiss-Prot
      Q0VAN6, Q5QJ74
      UniProtKB/TrEMBL
      Q0VAN5
      Related
      ENSP00000437184.1, ENST00000529397.5
      Conserved Domains (4) summary
      COG4886
      Location:47225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5275
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:191304
      LRR_9; Leucine-rich repeat
      cl00155
      Location:345419
      UBQ; Ubiquitin-like proteins
    2. NM_001363644.2NP_001350573.1  tubulin-specific chaperone cofactor E-like protein

      Status: VALIDATED

      Source sequence(s)
      AP000646, AP001929
      Consensus CDS
      CCDS31692.1
      UniProtKB/Swiss-Prot
      Q0VAN6, Q5QJ74
      UniProtKB/TrEMBL
      Q0VAN5
      Related
      ENSP00000507873.1, ENST00000683345.1
      Conserved Domains (4) summary
      COG4886
      Location:47225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5275
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:191304
      LRR_9; Leucine-rich repeat
      cl00155
      Location:345419
      UBQ; Ubiquitin-like proteins
    3. NM_152715.5NP_689928.3  tubulin-specific chaperone cofactor E-like protein

      See identical proteins and their annotated locations for NP_689928.3

      Status: VALIDATED

      Source sequence(s)
      AP000646, AP001929
      Consensus CDS
      CCDS31692.1
      UniProtKB/Swiss-Prot
      Q0VAN6, Q5QJ74
      UniProtKB/TrEMBL
      Q0VAN5
      Related
      ENSP00000403925.2, ENST00000422003.6
      Conserved Domains (4) summary
      COG4886
      Location:47225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:5275
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:191304
      LRR_9; Leucine-rich repeat
      cl00155
      Location:345419
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      121024102..121090776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      121047848..121114522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)