FZD3 frizzled class receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FZD3provided by HGNC
Official Full Name: frizzled class receptor 3provided by HGNC
Primary source: HGNC:HGNC:4041
See related: Ensembl:ENSG00000104290 MIM:606143; AllianceGenome:HGNC:4041
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Fz-3
Summary: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Expression: Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (28494212..28574258)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (28772375..28852426)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (28351729..28431775)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
Title: WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway.
Title: FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway.
Frizzled-3 suppression overcomes multidrug chemoresistance by Wnt/beta-catenin signaling pathway inhibition in hepatocellular carcinoma cells.
Title: Frizzled-3 suppression overcomes multidrug chemoresistance by Wnt/β-catenin signaling pathway inhibition in hepatocellular carcinoma cells.
Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.
Title: Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.
MiR-340 regulates the growth and metabolism of renal cell carcinoma cells by targeting frizzled class receptor 3.
Title: MiR-340 regulates the growth and metabolism of renal cell carcinoma cells by targeting frizzled class receptor 3.
Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3.
Title: Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3.
In breast cancer cells 5'-tiRNA(Val) functions as a new tumor-suppressor through inhibition of FZD3/Wnt/beta-Catenin signaling pathway.
Title: A tRNA fragment, 5'-tiRNA(Val), suppresses the Wnt/β-catenin signaling pathway by targeting FZD3 in breast cancer.
Changes in gene-expression patterns mediated by FZD3 activity occur in the absence of nuclear beta-catenin function, thus representing an important therapeutic target for the melanoma patients whose disease progresses independent of canonical WNT signaling
Title: Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling.
This study identified Circular RNA circ-CBFB as a sponge of miR-607, which targeted FZD3.
Title: Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.
schizophrenia may be related to some polymorphisms of gene FZD3 that are in stronger linkage disequilibrium to Chinese than to the other populations studied (Meta-Analysis)
Title: A meta-analysis of FZD3 gene polymorphisms and their association with schizophrenia.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH122525 (e-PCR)
- UniSTS:138527

D7S3207 (e-PCR)
- UniSTS:229489

SGC31127 (e-PCR)
- UniSTS:15738

RH15824 (e-PCR)
- UniSTS:18846

RH12433 (e-PCR)
- UniSTS:64961

A007B14 (e-PCR)
- UniSTS:28870

STS-AA024552 (e-PCR)
- UniSTS:46050

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IC Inferred by Curator more info	PubMed
enables Wnt receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell proliferation in midbrain	IEA Inferred from Electronic Annotation more info
involved_in commissural neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in midbrain morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in motor neuron migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle, embryonic	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in serotonergic neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-3

Names: frizzled 3, seven transmembrane spanning receptor; frizzled family receptor 3; frizzled homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029723.1 RefSeqGene

Range

5008..85054

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_859

mRNA and Protein(s)

NM_001412905.1 → NP_001399834.1 frizzled-3 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412906.1 → NP_001399835.1 frizzled-3 isoform 3

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412908.1 → NP_001399837.1 frizzled-3 isoform 5

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412909.1 → NP_001399838.1 frizzled-3 isoform 6

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412910.1 → NP_001399839.1 frizzled-3 isoform 6

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412911.1 → NP_001399840.1 frizzled-3 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC011132

UniProtKB/Swiss-Prot

A8K615, Q9NPG1
NM_001412912.1 → NP_001399841.1 frizzled-3 isoform 7

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412913.1 → NP_001399842.1 frizzled-3 isoform 7

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412917.1 → NP_001399846.1 frizzled-3 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412919.1 → NP_001399848.1 frizzled-3 isoform 6

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412921.1 → NP_001399850.1 frizzled-3 isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412922.1 → NP_001399851.1 frizzled-3 isoform 9

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412924.1 → NP_001399853.1 frizzled-3 isoform 10

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412925.1 → NP_001399854.1 frizzled-3 isoform 10

Status: REVIEWED

Source sequence(s)

AC011132
NM_001412927.1 → NP_001399856.1 frizzled-3 isoform 11

Status: REVIEWED

Source sequence(s)

AC011132
NM_017412.4 → NP_059108.1 frizzled-3 precursor

See identical proteins and their annotated locations for NP_059108.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AB039723, AC011132, BU676090, DA250029

Consensus CDS

CCDS6069.1

UniProtKB/Swiss-Prot

A8K615, Q9NPG1

Related

ENSP00000240093.3, ENST00000240093.8

Conserved Domains (2) summary

cd07449
Location:24 → 150

CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor

cd15033
Location:192 → 512

7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors
NM_145866.2 → NP_665873.1 frizzled-3 precursor

See identical proteins and their annotated locations for NP_665873.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC011132, AK291480, BU676090

Consensus CDS

CCDS6069.1

UniProtKB/Swiss-Prot

A8K615, Q9NPG1

Related

ENSP00000437489.1, ENST00000537916.2

Conserved Domains (2) summary

cd07449
Location:24 → 150

CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor

cd15033
Location:192 → 512

7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors

RNA

NR_182065.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182066.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182067.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182068.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182069.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182070.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_182071.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132
NR_197428.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

28494212..28574258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422238.1 → XP_047278194.1 frizzled-3 isoform X2
XM_017013843.2 → XP_016869332.1 frizzled-3 isoform X4
XM_047422239.1 → XP_047278195.1 frizzled-3 isoform X4
XM_017013844.2 → XP_016869333.1 frizzled-3 isoform X5
XM_017013842.2 → XP_016869331.1 frizzled-3 isoform X3
XM_017013841.2 → XP_016869330.1 frizzled-3 isoform X1

Conserved Domains (2) summary

cd15033
Location:125 → 445

7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors

cl02447
Location:1 → 83

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

28772375..28852426

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054361241.1 → XP_054217216.1 frizzled-3 isoform X4
XM_054361243.1 → XP_054217218.1 frizzled-3 isoform X4
XM_054361242.1 → XP_054217217.1 frizzled-3 isoform X5
XM_054361240.1 → XP_054217215.1 frizzled-3 isoform X3
XM_054361239.1 → XP_054217214.1 frizzled-3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001412907.1: Suppressed sequence

Description

NM_001412907.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.