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    KSR2 kinase suppressor of ras 2 [ Homo sapiens (human) ]

    Gene ID: 283455, updated on 28-Oct-2024

    Summary

    Official Symbol
    KSR2provided by HGNC
    Official Full Name
    kinase suppressor of ras 2provided by HGNC
    Primary source
    HGNC:HGNC:18610
    See related
    Ensembl:ENSG00000171435 MIM:610737; AllianceGenome:HGNC:18610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in brain (RPKM 1.7), adrenal (RPKM 0.5) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KSR2 in Genome Data Viewer
    Location:
    12q24.22-q24.23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (117453012..117968990, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (117440139..117956270, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117890817..118406795, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:117580597-117581796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117645205-117645705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117657550-117658106 Neighboring gene F-box protein 21 Neighboring gene MPRA-validated peak1985 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117670646-117670812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674186-117674690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674691-117675195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:117718941-117719440 Neighboring gene elongin C pseudogene 32 Neighboring gene nitric oxide synthase 1 Neighboring gene NOS1 1f and 1g alternate promoter region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117826376-117826876 Neighboring gene NOS1 1c alternate promoter Neighboring gene uncharacterized LOC105370012 Neighboring gene Sharpr-MPRA regulatory region 11046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118021615-118022115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066793-118067293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118066292-118066792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118078225-118078724 Neighboring gene uncharacterized LOC105370011 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118274024-118274569 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:118284773-118285290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118312867-118313667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4919 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118442171-118442363 Neighboring gene MPRA-validated peak1990 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24987 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7106 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:118489679-118490878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4921 Neighboring gene uncharacterized LOC124903030 Neighboring gene replication factor C subunit 5 Neighboring gene WD repeat and SOCS box containing 2 Neighboring gene V-set and immunoglobulin domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study link novel loci to endometriosis.
    EBI GWAS Catalog
    Genome-wide association study of biochemical traits in Korcula Island, Croatia.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kinase suppressor of Ras 2
    NP_775869.4
    XP_011536526.1
    XP_011536527.1
    XP_011536528.1
    XP_011536531.1
    XP_016874697.1
    XP_016874698.1
    XP_016874699.1
    XP_054227814.1
    XP_054227815.1
    XP_054227816.1
    XP_054227817.1
    XP_054227818.1
    XP_054227819.1
    XP_054227820.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173598.6NP_775869.4  kinase suppressor of Ras 2

      Status: VALIDATED

      Source sequence(s)
      AC073864, AC079127, AC084291, AC092936
      Consensus CDS
      CCDS61250.2
      UniProtKB/Swiss-Prot
      A0PJT2, Q3B828, Q6VAB6, Q8N775
      Related
      ENSP00000339952.4, ENST00000339824.7
      Conserved Domains (3) summary
      cd14153
      Location:665934
      PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
      pfam13543
      Location:24152
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cl00040
      Location:408464
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      117453012..117968990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538224.4XP_011536526.1  kinase suppressor of Ras 2 isoform X1

      See identical proteins and their annotated locations for XP_011536526.1

      Conserved Domains (3) summary
      cd00029
      Location:413455
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14153
      Location:663932
      PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
      pfam13543
      Location:24152
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    2. XM_011538225.4XP_011536527.1  kinase suppressor of Ras 2 isoform X3

      See identical proteins and their annotated locations for XP_011536527.1

      Conserved Domains (2) summary
      cd00029
      Location:292334
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14153
      Location:544813
      PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2
    3. XM_017019210.3XP_016874699.1  kinase suppressor of Ras 2 isoform X7

    4. XM_017019208.3XP_016874697.1  kinase suppressor of Ras 2 isoform X2

    5. XM_011538226.4XP_011536528.1  kinase suppressor of Ras 2 isoform X4

      Conserved Domains (3) summary
      cd00029
      Location:413455
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13543
      Location:24152
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cl21453
      Location:665739
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011538229.4XP_011536531.1  kinase suppressor of Ras 2 isoform X6

      Conserved Domains (2) summary
      cd00029
      Location:413455
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13543
      Location:24152
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    7. XM_017019209.3XP_016874698.1  kinase suppressor of Ras 2 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      117440139..117956270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371839.1XP_054227814.1  kinase suppressor of Ras 2 isoform X1

    2. XM_054371841.1XP_054227816.1  kinase suppressor of Ras 2 isoform X3

    3. XM_054371845.1XP_054227820.1  kinase suppressor of Ras 2 isoform X7

    4. XM_054371840.1XP_054227815.1  kinase suppressor of Ras 2 isoform X2

    5. XM_054371842.1XP_054227817.1  kinase suppressor of Ras 2 isoform X4

    6. XM_054371844.1XP_054227819.1  kinase suppressor of Ras 2 isoform X6

    7. XM_054371843.1XP_054227818.1  kinase suppressor of Ras 2 isoform X5