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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001159377.2 → NP_001152849.1 methenyltetrahydrofolate synthase domain-containing protein isoform 1
See identical proteins and their annotated locations for NP_001152849.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC009108, AK297726, BC112059
- Consensus CDS
-
CCDS54047.1
- UniProtKB/Swiss-Prot
- A8MQ77, B7ZLC0, B7ZLC2, D3DUM9, E9PAM1, Q2M296, Q9H878, Q9H954
- UniProtKB/TrEMBL
-
B4DN17
- Related
- ENSP00000354152.6, ENST00000360900.11
- Conserved Domains (2) summary
-
- cd12270
Location:307 → 378
- RRM_MTHFSD; RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
- cl00360
Location:10 → 207
- 5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
-
NM_001159378.2 → NP_001152850.1 methenyltetrahydrofolate synthase domain-containing protein isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) has alternate splice sites in the 5' coding region, compared to variant 1. The resulting isoform (2) is of the same size, but has a different internal segment, compared to isoform 1.
- Source sequence(s)
-
AC009108, AK297726, BC143707
- Consensus CDS
-
CCDS54048.1
- UniProtKB/TrEMBL
-
B4DN17
- Related
- ENSP00000370612.5, ENST00000381214.9
- Conserved Domains (2) summary
-
- COG0212
Location:10 → 211
- FAU1; 5-formyltetrahydrofolate cyclo-ligase [Coenzyme transport and metabolism]
- cd12270
Location:307 → 378
- RRM_MTHFSD; RNA recognition motif (RRM) found in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
-
NM_001159379.2 → NP_001152851.1 methenyltetrahydrofolate synthase domain-containing protein isoform 4
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) has alternate splice sites in the 5' coding region, compared to variant 1. The resulting isoform (4) is one aa shorter, and has a different internal segment, compared to isoform 1.
- Source sequence(s)
-
AC009108, AK297726
- Consensus CDS
-
CCDS58490.1
- UniProtKB/TrEMBL
-
B4DN17
- Related
- ENSP00000444003.2, ENST00000543303.6
- Conserved Domains (2) summary
-
- COG0212
Location:9 → 210
- FAU1; 5-formyltetrahydrofolate cyclo-ligase [Coenzyme transport and metabolism]
- cd12270
Location:306 → 377
- RRM_MTHFSD; RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
-
NM_001159380.2 → NP_001152852.1 methenyltetrahydrofolate synthase domain-containing protein isoform 5
See identical proteins and their annotated locations for NP_001152852.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) has an alternate splice site in the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC009108, BC143705
- UniProtKB/TrEMBL
-
B4DN17
- Conserved Domains (2) summary
-
- cd12270
Location:287 → 358
- RRM_MTHFSD; RNA recognition motif (RRM) found in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
- cl00360
Location:10 → 187
- 5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
-
NM_022764.3 → NP_073601.2 methenyltetrahydrofolate synthase domain-containing protein isoform 3
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (3) is one aa shorter, compared to isoform 1.
- Source sequence(s)
-
AC009108, AI263847, AK023955, AK297726
- Consensus CDS
-
CCDS42211.1
- UniProtKB/TrEMBL
-
B4DN17
- Related
- ENSP00000489295.1, ENST00000634347.1
- Conserved Domains (2) summary
-
- cd12270
Location:306 → 377
- RRM_MTHFSD; RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
- cl00360
Location:9 → 206
- 5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
RNA
-
NR_027489.2 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (6) has alternate splice sites and an additional exon in the 5' coding region, which results in an earlier stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate and is unlikely to make a functional protein.
- Source sequence(s)
-
AC009108, AK096836
-
NR_027490.2 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (7) has an additional segment in the 5' coding region, which includes a stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate and is unlikely to make a functional protein.
- Source sequence(s)
-
AC009108, AK297726, BC143703