PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3CGprovided by HGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by HGNC
Primary source: HGNC:HGNC:8978
See related: Ensembl:ENSG00000105851 MIM:601232; AllianceGenome:HGNC:8978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI3K; PIK3; IMD97; PI3CG; PI3Kgamma; p110gamma; p120-PI3K
Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]
Expression: Broad expression in bone marrow (RPKM 12.4), lymph node (RPKM 9.1) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (106865282..106908980)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (108181318..108225014)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (106505727..106549425)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3Kgamma maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Title: PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Hypoxia Sensing of beta-Adrenergic Receptor Is Regulated by Endosomal PI3Kgamma.
Title: Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.
High expression of the phosphoinositide 3-kinase p11gamma isoform can predict poor prognosis of non-small cell lung cancer.
Title: High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.
PI3Kgamma is a novel regulator of TNFalpha signaling in the human colon cell line HT29/B6.
Title: PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.
Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kgamma activation in patients with chronic Chagas cardiomyopathy.
Title: Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.
A PI3Kgamma mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Title: A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Disease-related mutations in PI3Kgamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
Title: Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
Polymorphism in the catalytic subunit of the PI3Kgamma gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.
Title: Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.
MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma.
Title: MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma.
G protein betagamma translocation to the Golgi apparatus activates MAPK via p110gamma-p101 heterodimers.
Title: G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.

Submit: New GeneRIF Correction See all GeneRIFs (323)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 97 with autoinflammation MedGen: C5676946 OMIM: 619802 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. EBI GWAS Catalog EBI GWAS CatalogPubMed
New gene functions in megakaryopoiesis and platelet formation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	HIV-1 Nef interacts with AKT1 and PI3K via its C and N terminal extremity, respectively	PubMed
	nef	HIV-1 Nef activation of AKT1 is mediated by PI3K in peripheral blood lymphocytes	PubMed
	nef	HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression	PubMed
	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta, leading to activation of PI3K and AKT and inactivation of PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells	PubMed
	tat	Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed
Vpr	vpr	HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed
	vpr	HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X83368 (e-PCR)
- UniSTS:39720

G36360 (e-PCR)
- UniSTS:4393

SHGC-82136 (e-PCR)
- UniSTS:103055

SHGC-35564 (e-PCR)
- UniSTS:7166

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in T cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in T cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in adaptive immune response	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in mast cell degranulation	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cardiac muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil extravasation	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet aggregation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion mediated by integrin	TAS Traceable Author Statement more info	PubMed
involved_in respiratory burst involved in defense response	TAS Traceable Author Statement more info	PubMed
involved_in secretory granule localization	IEA Inferred from Electronic Annotation more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	EXP Inferred from Experiment more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IB	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IB	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Names: 1-phosphatidylinositol 3-kinase; PI3-kinase subunit gamma; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphoinositide-3-kinase gamma catalytic subunit; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG

NP_001269355.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NP_001269356.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NP_002640.2

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_005250500.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_011514618.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_011514619.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_016867817.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_047276435.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_047276436.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_047276437.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214385.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214386.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214387.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214388.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214389.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214390.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_054214391.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050579.1 RefSeqGene

Range

5005..48703

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001282426.2 → NP_001269355.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_001269355.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AA810265, AC005018, AK292684, BC035683, BX648341, X83368

Consensus CDS

CCDS5739.1

UniProtKB/Swiss-Prot

A4D0Q6, P48736, Q8IV23, Q9BZC8

UniProtKB/TrEMBL

A8K9G9

Related

ENSP00000419260.1, ENST00000496166.6

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
NM_001282427.2 → NP_001269356.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_001269356.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AA810265, AC005018, AK292684, BC035683, X83368

Consensus CDS

CCDS5739.1

UniProtKB/Swiss-Prot

A4D0Q6, P48736, Q8IV23, Q9BZC8

UniProtKB/TrEMBL

A8K9G9

Related

ENSP00000392258.2, ENST00000440650.6

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
NM_002649.3 → NP_002640.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_002640.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AA810265, AC005018, BC035683, X83368

Consensus CDS

CCDS5739.1

UniProtKB/Swiss-Prot

A4D0Q6, P48736, Q8IV23, Q9BZC8

UniProtKB/TrEMBL

A8K9G9

Related

ENSP00000352121.3, ENST00000359195.3

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

106865282..106908980

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017012328.2 → XP_016867817.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A8K9G9
XM_011516316.2 → XP_011514618.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3

UniProtKB/TrEMBL

A8K9G9

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cl21453
Location:729 → 1011

PKc_like; Protein Kinases, catalytic domain
XM_011516317.2 → XP_011514619.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X4

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cl21453
Location:729 → 876

PKc_like; Protein Kinases, catalytic domain
XM_047420481.1 → XP_047276437.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X5
XM_005250443.4 → XP_005250500.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

See identical proteins and their annotated locations for XP_005250500.1

UniProtKB/Swiss-Prot

A4D0Q6, P48736, Q8IV23, Q9BZC8

UniProtKB/TrEMBL

A8K9G9

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_047420480.1 → XP_047276436.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X4
XM_047420479.1 → XP_047276435.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

108181318..108225014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358411.1 → XP_054214386.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2
XM_054358412.1 → XP_054214387.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3
XM_054358414.1 → XP_054214389.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X4
XM_054358416.1 → XP_054214391.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X5
XM_054358410.1 → XP_054214385.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

UniProtKB/Swiss-Prot

A4D0Q6, P48736, Q8IV23, Q9BZC8
XM_054358415.1 → XP_054214390.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X4
XM_054358413.1 → XP_054214388.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3