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    LRRC37A2 leucine rich repeat containing 37 member A2 [ Homo sapiens (human) ]

    Gene ID: 474170, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LRRC37A2provided by HGNC
    Official Full Name
    leucine rich repeat containing 37 member A2provided by HGNC
    Primary source
    HGNC:HGNC:32404
    See related
    Ensembl:ENSG00000238083 MIM:616556; AllianceGenome:HGNC:32404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC37
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in SNARE complex disassembly and protein transport. Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 18.7), bone marrow (RPKM 5.7) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See LRRC37A2 in Genome Data Viewer
    Location:
    17q21.31-q21.32
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46372792..47049128)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47234775..47910589)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44589834..44633014)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene leucine rich repeat containing 37A Neighboring gene ARF like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene RNA, 7SL, cytoplasmic 199, pseudogene Neighboring gene ARF like GTPase 17A Neighboring gene RDM1 pseudogene 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44704776-44705308 Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene vesicle-associated membrane protein 5-like Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44809975-44810751 Neighboring gene Sharpr-MPRA regulatory region 12503 Neighboring gene Sharpr-MPRA regulatory region 3126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44849369-44850026 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44850027-44850682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44850683-44851340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44851341-44851996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44853512-44854187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44859348-44860034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44862602-44863519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44863520-44864436 Neighboring gene ribosomal protein S7 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44886481-44887010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44887011-44887538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44891812-44892716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44897113-44897700 Neighboring gene uncharacterized LOC101929777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44909071-44909718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44909719-44910366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44910367-44911014 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:44922250-44922415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44941567-44942392 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:44941221-44941463 Neighboring gene Wnt family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44953785-44954385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44955695-44956194 Neighboring gene Sharpr-MPRA regulatory region 3811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44967346-44967846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:44971730-44972350 Neighboring gene uncharacterized LOC112268191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45000502-45001226 Neighboring gene Wnt family member 9B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45008344-45009543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45020222-45021158 Neighboring gene RNA, U6atac small nuclear 3, pseudogene Neighboring gene long intergenic non-protein coding RNA 1974 Neighboring gene Sharpr-MPRA regulatory region 11668 Neighboring gene GOSR2 divergent transcript Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:45054724-45055404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45055405-45056084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8620 Neighboring gene uncharacterized LOC101927060 Neighboring gene Sharpr-MPRA regulatory region 6393 Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene microRNA 5089 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene MPRA-validated peak2870 silencer Neighboring gene reprimo like Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45145515-45146016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45146017-45146516 Neighboring gene uncharacterized LOC124904015 Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45175453-45176078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8621 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:45197166-45197776 Neighboring gene protein GVQW1-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495 Neighboring gene cell division cycle 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. Bekpen C, et al. Genome Res, 2012 Jun. PMID 22419166, Free PMC Article
    2. Evolutionary dynamism of the primate LRRC37 gene family. Giannuzzi G, et al. Genome Res, 2013 Jan. PMID 23064749, Free PMC Article
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
    4. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ45049

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 37A2
    Names
    c114 SLIT-like testicular protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006607.3 → NP_001006608.2  leucine-rich repeat-containing protein 37A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001006608.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138645
      Consensus CDS
      CCDS42353.1
      UniProtKB/Swiss-Prot
      A6NM11, B7ZMC3
      UniProtKB/TrEMBL
      A0A0G2JNC9
      Related
      ENSP00000459551.1, ENST00000576629.6
      Conserved Domains (5) summary
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1468 → 1613
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    2. NM_001385803.1 → NP_001372732.1  leucine-rich repeat-containing protein 37A2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC138645
      UniProtKB/TrEMBL
      A0A0G2JNC9
      Conserved Domains (7) summary
      COG4886
      Location:866 → 1045
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      PRK10263
      Location:206 → 704
      PRK10263; DNA translocase FtsK; Provisional
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      NF033395
      Location:113 → 266
      fibronec_SfbI; fibronectin-binding protein SfbI
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1468 → 1613
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:560 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      46372792..47049128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436147.1 → XP_047292103.1  leucine-rich repeat-containing protein 37A2 isoform X12

    2. XM_047436145.1 → XP_047292101.1  leucine-rich repeat-containing protein 37A2 isoform X11

    3. XM_047436146.1 → XP_047292102.1  leucine-rich repeat-containing protein 37A2 isoform X16

    4. XM_047436143.1 → XP_047292099.1  leucine-rich repeat-containing protein 37A2 isoform X6

    5. XM_047436144.1 → XP_047292100.1  leucine-rich repeat-containing protein 37A2 isoform X8

    6. XM_024450773.2 → XP_024306541.1  leucine-rich repeat-containing protein 37A2 isoform X15

      UniProtKB/TrEMBL
      A8MUI5
      Conserved Domains (5) summary
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1468 → 1602
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:571 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family
      cl28087
      Location:144 → 704
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    7. XM_011524842.4 → XP_011523144.1  leucine-rich repeat-containing protein 37A2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JNC9
      Conserved Domains (5) summary
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1468 → 1578
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    8. XM_011524843.4 → XP_011523145.1  leucine-rich repeat-containing protein 37A2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JNC9
      Conserved Domains (5) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1419 → 1564
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    9. XM_011524841.4 → XP_011523143.1  leucine-rich repeat-containing protein 37A2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNC9
      Conserved Domains (5) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 952
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1444 → 1589
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    10. XM_011524844.4 → XP_011523146.1  leucine-rich repeat-containing protein 37A2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JNC9
      Conserved Domains (5) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:914 → 956
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:868 → 925
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1417 → 1562
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    11. XM_011524848.4 → XP_011523150.1  leucine-rich repeat-containing protein 37A2 isoform X7

      UniProtKB/TrEMBL
      A0A994J7J8
      Related
      ENSP00000516210.1, ENST00000706058.1
      Conserved Domains (4) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:868 → 920
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1368 → 1513
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    12. XM_011524846.4 → XP_011523148.1  leucine-rich repeat-containing protein 37A2 isoform X5

      UniProtKB/TrEMBL
      A0A994J7J8
      Conserved Domains (3) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam14914
      Location:1393 → 1538
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    13. XM_047436141.1 → XP_047292097.1  leucine-rich repeat-containing protein 37A2 isoform X13

    14. XM_047436142.1 → XP_047292098.1  leucine-rich repeat-containing protein 37A2 isoform X14

    15. XM_011524850.4 → XP_011523152.1  leucine-rich repeat-containing protein 37A2 isoform X10

      Conserved Domains (4) summary
      sd00031
      Location:868 → 890
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    16. XM_011524849.3 → XP_011523151.1  leucine-rich repeat-containing protein 37A2 isoform X9

      Conserved Domains (4) summary
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    RNA

    1. XR_007065300.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      195713..378581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328575.1 → XP_054184550.1  leucine-rich repeat-containing protein 37A2 isoform X17

    2. XM_054328574.1 → XP_054184549.1  leucine-rich repeat-containing protein 37A2 isoform X11

    3. XM_054328573.1 → XP_054184548.1  leucine-rich repeat-containing protein 37A2 isoform X6

    4. XM_054328577.1 → XP_054184552.1  leucine-rich repeat-containing protein 37A2 isoform X12

    5. XM_054328576.1 → XP_054184551.1  leucine-rich repeat-containing protein 37A2 isoform X12

    6. XM_054328578.1 → XP_054184553.1  leucine-rich repeat-containing protein 37A2 isoform X18

    RNA

    1. XR_008485599.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1032151..1075353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47234775..47910589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316266.1 → XP_054172241.1  leucine-rich repeat-containing protein 37A2 isoform X12

    2. XM_054316263.1 → XP_054172238.1  leucine-rich repeat-containing protein 37A2 isoform X11

    3. XM_054316264.1 → XP_054172239.1  leucine-rich repeat-containing protein 37A2 isoform X20

    4. XM_054316265.1 → XP_054172240.1  leucine-rich repeat-containing protein 37A2 isoform X21

    5. XM_054316262.1 → XP_054172237.1  leucine-rich repeat-containing protein 37A2 isoform X19

    6. XM_054316257.1 → XP_054172232.1  leucine-rich repeat-containing protein 37A2 isoform X6

    7. XM_054316259.1 → XP_054172234.1  leucine-rich repeat-containing protein 37A2 isoform X8

    8. XM_054316253.1 → XP_054172228.1  leucine-rich repeat-containing protein 37A2 isoform X2

    9. XM_054316254.1 → XP_054172229.1  leucine-rich repeat-containing protein 37A2 isoform X3

    10. XM_054316252.1 → XP_054172227.1  leucine-rich repeat-containing protein 37A2 isoform X1

    11. XM_054316255.1 → XP_054172230.1  leucine-rich repeat-containing protein 37A2 isoform X4

    12. XM_054316258.1 → XP_054172233.1  leucine-rich repeat-containing protein 37A2 isoform X7

    13. XM_054316256.1 → XP_054172231.1  leucine-rich repeat-containing protein 37A2 isoform X5

    14. XM_054316261.1 → XP_054172236.1  leucine-rich repeat-containing protein 37A2 isoform X10

    15. XM_054316260.1 → XP_054172235.1  leucine-rich repeat-containing protein 37A2 isoform X9

    RNA

    1. XR_008484825.1 RNA Sequence

    2. XR_008484824.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NM11.2 GenPept UniProtKB/Swiss-Prot:A6NM11

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