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    ZRANB2 zinc finger RANBP2-type containing 2 [ Homo sapiens (human) ]

    Gene ID: 9406, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZRANB2provided by HGNC
    Official Full Name
    zinc finger RANBP2-type containing 2provided by HGNC
    Primary source
    HGNC:HGNC:13058
    See related
    Ensembl:ENSG00000132485 MIM:604347; AllianceGenome:HGNC:13058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIS; ZIS1; ZIS2; ZNF265
    Summary
    Enables RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 47.3), lymph node (RPKM 37.7) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ZRANB2 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (71063291..71081035, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70941292..70959042, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71528974..71546718, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene MPRA-validated peak284 silencer Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene prostaglandin E receptor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene microRNA 186 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:71927989-71928559 Neighboring gene neuronal growth regulator 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:72203394-72203980 Neighboring gene NEGR1 intronic transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene. Nakano M, et al. Gene, 1998 Dec 28. PMID 9931435
    2. Crystallization of a ZRANB2-RNA complex. Loughlin FE, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Dec 1. PMID 19052380, Free PMC Article
    3. ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome. Yang YH, et al. Mol Biol Rep, 2013 Sep. PMID 23666063
    4. The structure of the zinc finger domain from human splicing factor ZNF265 fold. Plambeck CA, et al. J Biol Chem, 2003 Jun 20. PMID 12657633
    5. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data identify Aletrnative splicing programs controlled by ZRANB2 and SYF2 and converging on ECT2, that participate to breast cancer cell resistance to doxorubicin.
      Title: ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.
    2. ZRANB2 is part of the supraspliceosome and causes differential splicing of numerous primary transcripts, some of which might have a role in cancer.
      Title: ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome.
    3. Crystallization of a ZRANB2-RNA complex
      Title: Crystallization of a ZRANB2-RNA complex.
    4. sites responsible for MRNA binding have been characterized.
      Title: The structure of the zinc finger domain from human splicing factor ZNF265 fold.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41119, DKFZp686J1831, DKFZp686N09117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger Ran-binding domain-containing protein 2
    Names
    zinc finger protein 265
    zinc finger, RAN-binding domain containing 2
    zinc-finger, splicing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005455.5 → NP_005446.2  zinc finger Ran-binding domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_005446.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL136945, AL512443, BC039814, BU677906, DA523601
      Consensus CDS
      CCDS660.1
      UniProtKB/Swiss-Prot
      O95218
      Related
      ENSP00000254821.6, ENST00000254821.10
      Conserved Domains (2) summary
      smart00547
      Location:67 → 91
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:13 → 34
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. NM_203350.3 → NP_976225.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_976225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AF065391, AL512443, BC033648, BU677906, DA523601
      Consensus CDS
      CCDS659.1
      UniProtKB/Swiss-Prot
      D3DQ75, O95218, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
      Related
      ENSP00000359958.3, ENST00000370920.8
      Conserved Domains (2) summary
      smart00547
      Location:67 → 91
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:13 → 34
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      71063291..71081035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434733.1 → XP_047290689.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

      Related
      ENSP00000482026.1, ENST00000611683.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      70941292..70959042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339678.1 → XP_054195653.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95218.2 GenPept UniProtKB/Swiss-Prot:O95218

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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