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    ZNF503 zinc finger protein 503 [ Homo sapiens (human) ]

    Gene ID: 84858, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF503provided by HGNC
    Official Full Name
    zinc finger protein 503provided by HGNC
    Primary source
    HGNC:HGNC:23589
    See related
    Ensembl:ENSG00000165655 MIM:613902; AllianceGenome:HGNC:23589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Nlz2; NOLZ1; NOLZ-1
    Summary
    Predicted to enable metal ion binding activity. Involved in G1 to G0 transition involved in cell differentiation; negative regulation of cell population proliferation; and negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in kidney (RPKM 5.4), prostate (RPKM 1.9) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF503 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75279725..75401916, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (76153243..76275966, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (77039483..77161674, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 25 Neighboring gene high mobility group AT-hook 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2515 Neighboring gene ZNF503 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:77142242-77143441 Neighboring gene uncharacterized LOC124902461 Neighboring gene sperm autoantigenic protein 17 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:77160524-77161024 Neighboring gene VISTA enhancer hs484 Neighboring gene ZNF503 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:77165968-77166707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:77166708-77167448 Neighboring gene uncharacterized LOC101929234 Neighboring gene uncharacterized LOC107984293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:77191190-77191690

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032772.6NP_116161.2  zinc finger protein 503

      See identical proteins and their annotated locations for NP_116161.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC010997, AI701640, BC011625, BQ574961
      Consensus CDS
      CCDS7350.1
      UniProtKB/Swiss-Prot
      Q8NAC5, Q96E25, Q96F45, Q96IJ0
      UniProtKB/TrEMBL
      A8K2P6
      Related
      ENSP00000361602.4, ENST00000372524.5
      Conserved Domains (2) summary
      sd00017
      Location:516542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12402
      Location:355415
      nlz1; NocA-like zinc-finger protein 1

    RNA

    1. NR_120651.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains three alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010997, AI522172, BX105802

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      75279725..75401916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      76153243..76275966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)