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    jmjc-1 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [ Caenorhabditis elegans ]

    Gene ID: 171932, updated on 2-Nov-2024

    Summary

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    Official Symbol
    jmjc-1
    Official Full Name
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    Primary source
    WormBase:WBGene00020902
    Locus tag
    CELE_T28F2.4
    See related
    AllianceGenome:WB:WBGene00020902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Involved in several processes, including response to ethanol; response to heat; and response to osmotic stress. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See jmjc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (3631091..3636485, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Seven cysteines N-terminal domain-containing protein Neighboring gene Carbonic anhydrase Neighboring gene Protein LAZ1;Vacuolar protein sorting-associated protein 13D Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans. Kuzmanov A, et al. Mol Cell Biol, 2014 Mar. PMID 24421384, Free PMC Article
    2. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
    3. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    5. SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. Kirienko NV, et al. EMBO J, 2010 Feb 17. PMID 20057358, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    NP_001021644.1
    • Confirmed by transcript evidence
    NP_001021645.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3631091..3636485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026473.7 → NP_001021644.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G8XYY5, O01658
      Conserved Domains (1) summary
      pfam08007
      Location:317 → 662
      Cupin_4; Cupin superfamily protein

    2. NM_001026474.4 → NP_001021645.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01658
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01658.2

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