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    OR3A1 olfactory receptor family 3 subfamily A member 1 [ Homo sapiens (human) ]

    Gene ID: 4994, updated on 2-Nov-2024

    Summary

    Official Symbol
    OR3A1provided by HGNC
    Official Full Name
    olfactory receptor family 3 subfamily A member 1provided by HGNC
    Primary source
    HGNC:HGNC:8282
    See related
    Ensembl:ENSG00000180090 AllianceGenome:HGNC:8282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR40; OLFRA03; OR17-40; OR17-82
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See OR3A1 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3291017..3298360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3176811..3187684, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3194311..3201654, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily D member 4 Neighboring gene olfactory receptor family 1 subfamily D member 3 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 2 Neighboring gene olfactory receptor family 3 subfamily A member 4 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 1 subfamily AC member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 3A1
    Names
    Olfactory receptor-like protein OR17-82
    olfactory receptor 17-40
    olfactory receptor OR17-15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002550.3NP_002541.2  olfactory receptor 3A1

      See identical proteins and their annotated locations for NP_002541.2

      Status: VALIDATED

      Source sequence(s)
      AC087498
      Consensus CDS
      CCDS11023.1
      UniProtKB/Swiss-Prot
      P47881, Q4VB06, Q6IFM4
      UniProtKB/TrEMBL
      A0A126GVP1, A0A126GWJ3
      Related
      ENSP00000313803.1, ENST00000323404.2
      Conserved Domains (2) summary
      cd14964
      Location:3054
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:28304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3291017..3298360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3176811..3187684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316287.1XP_054172262.1  olfactory receptor 3A1 isoform X1

      UniProtKB/TrEMBL
      A0A126GWI0