myrf-2 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: myrf-2
Official Full Name: Myelin regulatory factor homolog 2, N-terminal
Primary source: WormBase:WBGene00008999
Locus tag: CELE_F21A10.2
See related: AllianceGenome:WB:WBGene00008999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and protein autoprocessing. Predicted to be located in apical plasma membrane and endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor) and MYRFL (myelin regulatory factor like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See myrf-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (10180958..10194377, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYRF-1 and MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans
Title: Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21A10.3 (e-PCR)
- UniSTS:316590

F21A10.2 (e-PCR)
- UniSTS:312558

F21A10.4 (e-PCR)
- UniSTS:312559

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoprocessing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Myelin regulatory factor homolog 2, N-terminal

NP_001257095.1

Partially confirmed by transcript evidence

NP_001367016.1

Confirmed by transcript evidence

NP_001367259.1

Confirmed by transcript evidence

NP_001379023.1

Confirmed by transcript evidence

NP_509709.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10180958..10194377 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392832.1 → NP_001379023.1 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05224
Location:252 → 402

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:751 → 884

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl16452
Location:449 → 557

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
NM_077308.7 → NP_509709.2 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509709.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D9PTN5

Conserved Domains (4) summary

pfam05224
Location:303 → 453

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:500 → 561

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:570 → 605

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:802 → 935

MRF_C2; Myelin gene regulatory factor C-terminal domain 2
NM_001270166.4 → NP_001257095.1 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257095.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D9PTN4, D9PTN5, G5EF12, Q8MQ67, Q9U3I3

Conserved Domains (4) summary

pfam05224
Location:363 → 513

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13884
Location:560 → 621

Peptidase_S74; Chaperone of endosialidase

pfam13887
Location:630 → 665

MRF_C1; Myelin gene regulatory factor -C-terminal domain 1

pfam13888
Location:862 → 995

MRF_C2; Myelin gene regulatory factor C-terminal domain 2
NM_001381079.1 → NP_001367016.1 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05224
Location:301 → 451

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:800 → 933

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl16452
Location:498 → 606

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
NM_001381080.1 → NP_001367259.1 Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam05224
Location:298 → 448

NDT80_PhoG; NDT80 / PhoG like DNA-binding family

pfam13888
Location:797 → 930

MRF_C2; Myelin gene regulatory factor C-terminal domain 2

cl16452
Location:495 → 603

Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins