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    MPZL2 myelin protein zero like 2 [ Homo sapiens (human) ]

    Gene ID: 10205, updated on 28-Oct-2024

    Summary

    Official Symbol
    MPZL2provided by HGNC
    Official Full Name
    myelin protein zero like 2provided by HGNC
    Primary source
    HGNC:HGNC:3496
    See related
    Ensembl:ENSG00000149573 MIM:604873; AllianceGenome:HGNC:3496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EVA; EVA1; DFNB111
    Summary
    Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in esophagus (RPKM 92.3), urinary bladder (RPKM 53.8) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MPZL2 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118253416..118264297, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118269772..118280653, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118124131..118135012, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule like Neighboring gene Sharpr-MPRA regulatory region 10108 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 18 Neighboring gene myelin protein zero like 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:118111758-118112957 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118122400-118122961 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118122962-118123522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5587 Neighboring gene Sharpr-MPRA regulatory region 14251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5588 Neighboring gene CD3 epsilon subunit of T-cell receptor complex Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5589 Neighboring gene CD3 delta subunit of T-cell receptor complex

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    myelin protein zero-like protein 2
    Names
    epithelial V-like antigen 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005797.4NP_005788.1  myelin protein zero-like protein 2 precursor

      See identical proteins and their annotated locations for NP_005788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AF275945, AW073724, DA163069
      Consensus CDS
      CCDS8393.1
      UniProtKB/Swiss-Prot
      A8K2R1, O60487
      Related
      ENSP00000278937.2, ENST00000278937.7
      Conserved Domains (1) summary
      cd05880
      Location:27142
      IgV_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1
    2. NM_144765.3NP_658911.1  myelin protein zero-like protein 2 precursor

      See identical proteins and their annotated locations for NP_658911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1 and is the shorter transcript.
      Source sequence(s)
      BC017774, DA163069
      Consensus CDS
      CCDS8393.1
      UniProtKB/Swiss-Prot
      A8K2R1, O60487
      Related
      ENSP00000408362.2, ENST00000438295.2
      Conserved Domains (1) summary
      cd05880
      Location:27142
      IgV_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      118253416..118264297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426229.1XP_047282185.1  myelin protein zero-like protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118269772..118280653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367432.1XP_054223407.1  myelin protein zero-like protein 2 isoform X1