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    FOXN2 forkhead box N2 [ Homo sapiens (human) ]

    Gene ID: 3344, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FOXN2provided by HGNC
    Official Full Name
    forkhead box N2provided by HGNC
    Primary source
    HGNC:HGNC:5281
    See related
    Ensembl:ENSG00000170802 MIM:143089; AllianceGenome:HGNC:5281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTLF
    Summary
    This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FOXN2 in Genome Data Viewer
    Location:
    2p16.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (48313659..48379295)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (48320267..48385262)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48541438..48606434)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 224 Neighboring gene uncharacterized LOC102724008 Neighboring gene NANOG hESC enhancer GRCh37_chr2:48510631-48511315 Neighboring gene uncharacterized LOC124907766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48541778-48542606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11479 Neighboring gene RNA, U4 small nuclear 49, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48617307-48617446 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48628408-48628554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48674501-48675002 Neighboring gene protein phosphatase 1 regulatory subunit 21 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48734957-48735731 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48735732-48736506 Neighboring gene STON1-GTF2A1L readthrough Neighboring gene RNA, U6 small nuclear 282, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48757286-48757833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:48787383-48787921 Neighboring gene stonin 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:48812672-48813306

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. Li C, et al. Genomics, 1992 Jul. PMID 1639393
    2. Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. Guo W, et al. Clin Biochem, 2011 Jul. PMID 21531217
    3. FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells. Liu XH, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33577027
    4. Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner. Song Y, et al. Cancer Lett, 2024 Jun 28. PMID 38705565
    5. Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia. Cheng CK, et al. Haematologica, 2016 Apr. PMID 26802049, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.
      Title: FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.
    2. Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.
      Title: Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.
    3. Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner.
      Title: Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner.
    4. HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.
      Title: HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.
    5. FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells.
      Title: FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells.
    6. The WT1-AS was under-expressed in cervical carcinoma and suppresses cervical cancer cell growth and aggressiveness via a miR-203a-5p/FOXN2 axis.
      Title: Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.
    7. The Ser365 and Ser369 sites in a conserved DSGYAS motif are critical for the degradation of FOXN2 by beta-Trcp and RSK2. Moreover, gain-of-function and loss-of-function studies show that FOXN2 impairs cell proliferation in vitro and in vivo and enhances the radiosensitivity of lung cancer.
      Title: β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.
    8. HTLF is a RUNX1 target whose down-regulation promotes genomic instability and correlates with complex cytogenetic abnormalities in acute myeloid leukemia patients.
      Title: Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.
    9. HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of gastric cardia adenocarcinoma.
      Title: Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein N2
    Names
    human T-cell leukemia virus enhancer factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375442.1 → NP_001362371.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-12 all encode the same isoform (a).
      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    2. NM_001375443.1 → NP_001362372.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    3. NM_001375444.1 → NP_001362373.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    4. NM_001375445.1 → NP_001362374.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    5. NM_001375446.1 → NP_001362375.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    6. NM_001375447.1 → NP_001362376.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    7. NM_001375448.1 → NP_001362377.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    8. NM_001375449.1 → NP_001362378.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    9. NM_001375450.1 → NP_001362379.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    10. NM_001375451.1 → NP_001362380.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    11. NM_001375452.1 → NP_001362381.1  forkhead box protein N2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC091485
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    12. NM_001375781.1 → NP_001362710.1  forkhead box protein N2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC091485
      UniProtKB/TrEMBL
      C9JTA7
      Related
      ENSP00000388486.1, ENST00000413569.5
      Conserved Domains (1) summary
      pfam00250
      Location:111 → 198
      Forkhead; Forkhead domain

    13. NM_002158.4 → NP_002149.2  forkhead box protein N2 isoform a

      See identical proteins and their annotated locations for NP_002149.2

      Status: REVIEWED

      Source sequence(s)
      AA827684, AC091485, BC063305
      Consensus CDS
      CCDS1838.1
      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Related
      ENSP00000343633.3, ENST00000340553.8
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    RNA

    1. NR_164686.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC091485

    2. NR_164691.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC091485

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      48313659..48379295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444107.1 → XP_047300063.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    2. XM_047444106.1 → XP_047300062.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    3. XM_047444110.1 → XP_047300066.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    4. XM_047444109.1 → XP_047300065.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    5. XM_047444108.1 → XP_047300064.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    6. XM_047444111.1 → XP_047300067.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    7. XM_047444105.1 → XP_047300061.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    8. XM_047444104.1 → XP_047300060.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    9. XM_005264283.3 → XP_005264340.1  forkhead box protein N2 isoform X1

      See identical proteins and their annotated locations for XP_005264340.1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2
      UniProtKB/TrEMBL
      Q6IS90
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    10. XM_047444112.1 → XP_047300068.1  forkhead box protein N2 isoform X2

    11. XM_047444113.1 → XP_047300069.1  forkhead box protein N2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      48320267..48385262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341687.1 → XP_054197662.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    2. XM_054341686.1 → XP_054197661.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    3. XM_054341690.1 → XP_054197665.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    4. XM_054341689.1 → XP_054197664.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    5. XM_054341688.1 → XP_054197663.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    6. XM_054341691.1 → XP_054197666.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    7. XM_054341685.1 → XP_054197660.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    8. XM_054341684.1 → XP_054197659.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    9. XM_054341683.1 → XP_054197658.1  forkhead box protein N2 isoform X1

      UniProtKB/Swiss-Prot
      P32314, Q15769, Q6P4Q2

    10. XM_054341692.1 → XP_054197667.1  forkhead box protein N2 isoform X2

    11. XM_054341693.1 → XP_054197668.1  forkhead box protein N2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32314.3 GenPept UniProtKB/Swiss-Prot:P32314

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