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    TUT7 terminal uridylyl transferase 7 [ Homo sapiens (human) ]

    Gene ID: 79670, updated on 28-Oct-2024

    Summary

    Official Symbol
    TUT7provided by HGNC
    Official Full Name
    terminal uridylyl transferase 7provided by HGNC
    Primary source
    HGNC:HGNC:25817
    See related
    Ensembl:ENSG00000083223 MIM:613467; AllianceGenome:HGNC:25817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPD6; TENT3B; ZCCHC6
    Summary
    Enables RNA uridylyltransferase activity and miRNA binding activity. Involved in RNA metabolic process and retrotransposon silencing by mRNA destabilization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 7.8), skin (RPKM 6.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TUT7 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (86287733..86354410, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98438962..98505744, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88902648..88969325, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264 Neighboring gene uncharacterized LOC124902194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28515 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88927255-88928092 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:88942866-88943573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19997 Neighboring gene ribosomal protein S6 pseudogene 13 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:89025123-89025720 Neighboring gene uncharacterized LOC102724080 Neighboring gene RNA, U2 small nuclear 36, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp666B142, DKFZp686F119, DKFZp686I1269, DKFZp686C11112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA 3' uridylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oocyte maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in polyuridylation-dependent mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrotransposon silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    terminal uridylyltransferase 7
    Names
    PAP associated domain containing 6
    TUTase 7
    zinc finger CCHC domain-containing protein 6
    zinc finger CCHC-type containing 6
    zinc finger, CCHC domain containing 6
    NP_001171988.1
    NP_001172003.1
    NP_001317647.1
    NP_078893.2
    XP_005252264.1
    XP_005252265.1
    XP_006717346.1
    XP_011517313.1
    XP_011517314.1
    XP_011517315.1
    XP_011517316.1
    XP_011517317.1
    XP_011517318.1
    XP_016870619.1
    XP_016870620.1
    XP_047279823.1
    XP_047279824.1
    XP_047279825.1
    XP_047279826.1
    XP_054219767.1
    XP_054219768.1
    XP_054219769.1
    XP_054219770.1
    XP_054219771.1
    XP_054219772.1
    XP_054219773.1
    XP_054219774.1
    XP_054219775.1
    XP_054219776.1
    XP_054219777.1
    XP_054219778.1
    XP_054219779.1
    XP_054219780.1
    XP_054219781.1
    XP_054219782.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185059.2NP_001171988.1  terminal uridylyltransferase 7 isoform 1

      See identical proteins and their annotated locations for NP_001171988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein isoform.
      Source sequence(s)
      AK055546, AK055948, BC015897, CR933643
      Consensus CDS
      CCDS35057.1
      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    2. NM_001185074.2NP_001172003.1  terminal uridylyltransferase 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two different regions of sequence, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK055546, AL832026, BC015897, BU734789, CA773862
      Consensus CDS
      CCDS55323.1
      Related
      ENSP00000365127.2, ENST00000375960.6
      Conserved Domains (5) summary
      cd05402
      Location:830902
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:12161232
      ZnF_C2HC; zinc finger
      pfam03828
      Location:9971050
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:11351214
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      cl11966
      Location:315360
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
    3. NM_001330718.2NP_001317647.1  terminal uridylyltransferase 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK055948, AL137849, AL353678, CN419677, CR933643, CR933644, DB156789
      Consensus CDS
      CCDS83383.1
      UniProtKB/TrEMBL
      X6R3Q3
      Related
      ENSP00000277141.6, ENST00000277141.10
    4. NM_024617.4NP_078893.2  terminal uridylyltransferase 7 isoform 1

      See identical proteins and their annotated locations for NP_078893.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein isoform.
      Source sequence(s)
      AK055546, BC015897, BC016387, BU734789, CA773862, DC377509
      Consensus CDS
      CCDS35057.1
      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
      Related
      ENSP00000365130.3, ENST00000375963.8
      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      86287733..86354410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252207.4XP_005252264.1  terminal uridylyltransferase 7 isoform X6

      See identical proteins and their annotated locations for XP_005252264.1

      Conserved Domains (3) summary
      cd05402
      Location:315427
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      COG5260
      Location:9791310
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    2. XM_006717283.2XP_006717346.1  terminal uridylyltransferase 7 isoform X2

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    3. XM_017015131.2XP_016870620.1  terminal uridylyltransferase 7 isoform X4

      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    4. XM_017015130.2XP_016870619.1  terminal uridylyltransferase 7 isoform X4

      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    5. XM_047423867.1XP_047279823.1  terminal uridylyltransferase 7 isoform X2

    6. XM_011519012.3XP_011517314.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_011517314.1

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    7. XM_011519016.2XP_011517318.1  terminal uridylyltransferase 7 isoform X5

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    8. XM_047423869.1XP_047279825.1  terminal uridylyltransferase 7 isoform X6

    9. XM_047423868.1XP_047279824.1  terminal uridylyltransferase 7 isoform X6

    10. XM_011519015.2XP_011517317.1  terminal uridylyltransferase 7 isoform X3

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    11. XM_011519011.3XP_011517313.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_011517313.1

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    12. XM_011519014.3XP_011517316.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_011517316.1

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    13. XM_011519013.3XP_011517315.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_011517315.1

      Conserved Domains (4) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:14521468
      ZnF_C2HC; zinc finger
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:13711450
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
    14. XM_005252208.3XP_005252265.1  terminal uridylyltransferase 7 isoform X7

      Conserved Domains (2) summary
      cd05402
      Location:10211138
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:12331286
      PAP_assoc; Cid1 family poly A polymerase
    15. XM_047423870.1XP_047279826.1  terminal uridylyltransferase 7 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      98438962..98505744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363799.1XP_054219774.1  terminal uridylyltransferase 7 isoform X4

      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
    2. XM_054363803.1XP_054219778.1  terminal uridylyltransferase 7 isoform X6

    3. XM_054363796.1XP_054219771.1  terminal uridylyltransferase 7 isoform X2

    4. XM_054363800.1XP_054219775.1  terminal uridylyltransferase 7 isoform X4

      UniProtKB/Swiss-Prot
      Q5H9T0, Q5VYS5, Q5VYS7, Q5VYS8, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6
    5. XM_054363797.1XP_054219772.1  terminal uridylyltransferase 7 isoform X2

    6. XM_054363794.1XP_054219769.1  terminal uridylyltransferase 7 isoform X1

    7. XM_054363793.1XP_054219768.1  terminal uridylyltransferase 7 isoform X1

    8. XM_054363801.1XP_054219776.1  terminal uridylyltransferase 7 isoform X5

    9. XM_054363804.1XP_054219779.1  terminal uridylyltransferase 7 isoform X6

    10. XM_054363802.1XP_054219777.1  terminal uridylyltransferase 7 isoform X6

    11. XM_054363798.1XP_054219773.1  terminal uridylyltransferase 7 isoform X3

    12. XM_054363792.1XP_054219767.1  terminal uridylyltransferase 7 isoform X1

    13. XM_054363795.1XP_054219770.1  terminal uridylyltransferase 7 isoform X1

    14. XM_054363807.1XP_054219782.1  terminal uridylyltransferase 7 isoform X9

    15. XM_054363805.1XP_054219780.1  terminal uridylyltransferase 7 isoform X7

    16. XM_054363806.1XP_054219781.1  terminal uridylyltransferase 7 isoform X8