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    FBXO11 F-box protein 11 [ Homo sapiens (human) ]

    Gene ID: 80204, updated on 28-Oct-2024

    Summary

    Official Symbol
    FBXO11provided by HGNC
    Official Full Name
    F-box protein 11provided by HGNC
    Primary source
    HGNC:HGNC:13590
    See related
    Ensembl:ENSG00000138081 MIM:607871; AllianceGenome:HGNC:13590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBR6; VIT1; FBX11; PRMT9; IDDFBA; UG063H01
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FBXO11 in Genome Data Viewer
    Location:
    2p16.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (47806920..47906498, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (47812869..47912466, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48034059..48133637, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374589 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48008525-48008706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11469 Neighboring gene mutS homolog 6 Neighboring gene ribosomal protein L36a pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15743 Neighboring gene Sharpr-MPRA regulatory region 9679 Neighboring gene RPS27A pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48129098-48129367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48131440-48132226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11471 Neighboring gene uncharacterized LOC100506235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48133799-48134583 Neighboring gene uncharacterized LOC105374590 Neighboring gene uncharacterized LOC105374592

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Depletion of F-box protein 11 (FBXO11) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12673, MGC44383

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 11
    Names
    protein arginine N-methyltransferase 9
    ubiquitin protein ligase E3 component n-recognin 6
    vitiligo-associated protein 1
    vitiligo-associated protein VIT-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008397.1 RefSeqGene

      Range
      4178..103756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190274.2NP_001177203.1  F-box only protein 11 isoform 4

      See identical proteins and their annotated locations for NP_001177203.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (4) has a distinct and longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006509, AC079807, AI879484, AY827075, DN994547
      Consensus CDS
      CCDS54357.1
      UniProtKB/Swiss-Prot
      A1L491, Q52ZP1, Q53EP7, Q53RT5, Q86XK2, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2
      UniProtKB/TrEMBL
      B4E272
      Related
      ENSP00000384823.4, ENST00000403359.8
      Conserved Domains (3) summary
      pfam12937
      Location:157200
      F-box-like
      pfam13229
      Location:664823
      Beta_helix; Right handed beta helix region
      cl19744
      Location:850891
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    2. NM_001374325.1NP_001361254.1  F-box only protein 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006509, AC079807
      Consensus CDS
      CCDS1837.1
      UniProtKB/TrEMBL
      B4E272
      Related
      ENST00000682975.1
      Conserved Domains (3) summary
      pfam12937
      Location:73116
      F-box-like
      pfam13229
      Location:580739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    3. NM_025133.4NP_079409.3  F-box only protein 11 isoform 1

      See identical proteins and their annotated locations for NP_079409.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC006509, AC079807, AI879484, AK315108
      Consensus CDS
      CCDS1837.1
      UniProtKB/TrEMBL
      B4E272
      Related
      ENSP00000385398.1, ENST00000402508.5
      Conserved Domains (3) summary
      pfam12937
      Location:73116
      F-box-like
      pfam13229
      Location:580739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      47806920..47906498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005015.2XP_016860504.1  F-box only protein 11 isoform X3

      UniProtKB/TrEMBL
      B4E272
      Conserved Domains (3) summary
      pfam12937
      Location:156199
      F-box-like
      pfam13229
      Location:663822
      Beta_helix; Right handed beta helix region
      cl19744
      Location:849890
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    2. XM_005264573.6XP_005264630.1  F-box only protein 11 isoform X2

      UniProtKB/TrEMBL
      B4E272
      Conserved Domains (4) summary
      TIGR03804
      Location:526568
      para_beta_helix; parallel beta-helix repeat (two copies)
      pfam12937
      Location:156201
      F-box-like; F-box-like
      pfam13229
      Location:663822
      Beta_helix; Right handed beta helix region
      cl19744
      Location:849917
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    3. XM_005264572.6XP_005264629.1  F-box only protein 11 isoform X1

      UniProtKB/TrEMBL
      B4E272
      Conserved Domains (4) summary
      TIGR03804
      Location:527569
      para_beta_helix; parallel beta-helix repeat (two copies)
      pfam12937
      Location:157202
      F-box-like; F-box-like
      pfam13229
      Location:664823
      Beta_helix; Right handed beta helix region
      cl19744
      Location:850918
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    4. XM_047445922.1XP_047301878.1  F-box only protein 11 isoform X7

    5. XM_017005016.3XP_016860505.1  F-box only protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A804HK63, B4E272
      Conserved Domains (4) summary
      TIGR03804
      Location:443485
      para_beta_helix; parallel beta-helix repeat (two copies)
      pfam12937
      Location:73118
      F-box-like; F-box-like
      pfam13229
      Location:580739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766834
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    6. XM_047445921.1XP_047301877.1  F-box only protein 11 isoform X6

    7. XM_047445920.1XP_047301876.1  F-box only protein 11 isoform X5

    8. XM_047445919.1XP_047301875.1  F-box only protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A804HK63
      Related
      ENSP00000507789.1, ENST00000683894.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      47812869..47912466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344043.1XP_054200018.1  F-box only protein 11 isoform X3

    2. XM_054344042.1XP_054200017.1  F-box only protein 11 isoform X2

    3. XM_054344041.1XP_054200016.1  F-box only protein 11 isoform X1

    4. XM_054344048.1XP_054200023.1  F-box only protein 11 isoform X7

    5. XM_054344044.1XP_054200019.1  F-box only protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A804HK63
    6. XM_054344047.1XP_054200022.1  F-box only protein 11 isoform X6

    7. XM_054344046.1XP_054200021.1  F-box only protein 11 isoform X5

    8. XM_054344045.1XP_054200020.1  F-box only protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A804HK63

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012167.1: Suppressed sequence

      Description
      NM_012167.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_018693.2: Suppressed sequence

      Description
      NM_018693.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.