ARL5B ARF like GTPase 5B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARL5Bprovided by HGNC
Official Full Name: ARF like GTPase 5Bprovided by HGNC
Primary source: HGNC:HGNC:23052
See related: Ensembl:ENSG00000165997 MIM:608909; AllianceGenome:HGNC:23052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARL8
Summary: ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Expression: Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p12.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (18659431..18681639)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (18678534..18700749)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (18948360..18970568)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.
Title: Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.
Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.
Title: Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.
Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.
Title: Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.
miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.
Title: miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.
Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.
Title: Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.
Depletion of either Arl5b or AP4 results in the accumulation of APP.
Title: Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.
Arl5b is a trans-golgi-network-localised small G protein that plays a key role in regulating transport along the endosome-trans-golgi network pathway
Title: Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.
Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Genome-wide shRNA screening identifies ARL5B, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 5B

Names: ADP ribosylation factor like GTPase 5B; ADP-ribosylation factor-like 5B; ADP-ribosylation factor-like 8; ADP-ribosylation factor-like protein 8; ADP-ribosylation-like factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178815.5 → NP_848930.1 ADP-ribosylation factor-like protein 5B

See identical proteins and their annotated locations for NP_848930.1

Status: VALIDATED

Source sequence(s)

AL133611, AL512641

Consensus CDS

CCDS7131.1

UniProtKB/Swiss-Prot

Q96KC2

UniProtKB/TrEMBL

B0YIW9

Related

ENSP00000366487.3, ENST00000377275.4

Conserved Domains (1) summary

cd04153
Location:3 → 175

Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

18659431..18681639

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005252400.2 → XP_005252457.1 ADP-ribosylation factor-like protein 5B isoform X1

See identical proteins and their annotated locations for XP_005252457.1

Conserved Domains (2) summary

smart00178
Location:8 → 148

SAR; Sar1p-like members of the Ras-family of small GTPases

cl21455
Location:3 → 147

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_005252401.5 → XP_005252458.1 ADP-ribosylation factor-like protein 5B isoform X2

See identical proteins and their annotated locations for XP_005252458.1

Conserved Domains (1) summary

cl38936
Location:1 → 138

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

18678534..18700749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365129.1 → XP_054221104.1 ADP-ribosylation factor-like protein 5B isoform X1
XM_054365130.1 → XP_054221105.1 ADP-ribosylation factor-like protein 5B isoform X2