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    MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10746, updated on 28-Oct-2024

    Summary

    Official Symbol
    MAP3K2provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:6854
    See related
    Ensembl:ENSG00000169967 MIM:609487; AllianceGenome:HGNC:6854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEKK2; MEKK2B
    Summary
    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAP3K2 in Genome Data Viewer
    Location:
    2q14.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (127298668..127388465, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (127733893..127823745, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128056244..128146041, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3852 silencer Neighboring gene WBP11 pseudogene 2 Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene RNA, U6 small nuclear 1147, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128109563-128110062 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:128111582-128112160 Neighboring gene uncharacterized LOC124906074 Neighboring gene MPRA-validated peak3853 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11931 Neighboring gene MAP3K2 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128158054-128158766 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128172964-128173726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128180062-128180860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128180861-128181657 Neighboring gene microRNA 4783 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies MAP3K2, a member of mitogen-activated protein kinase kinase family (serine/threonine protein kinase), is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    Names
    MAP/ERK kinase kinase 2
    MAPK/ERK kinase kinase 2
    MEK kinase 2
    MEKK 2
    NP_001358839.1
    NP_001358840.1
    NP_006600.3
    XP_047298945.1
    XP_047298946.1
    XP_047298947.1
    XP_054196193.1
    XP_054196194.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371910.2NP_001358839.1  mitogen-activated protein kinase kinase kinase 2

      Status: REVIEWED

      Source sequence(s)
      AC068282, AC110926
      Consensus CDS
      CCDS46404.1
      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
      Related
      ENSP00000507315.1, ENST00000682094.1
      Conserved Domains (2) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
    2. NM_001371911.1NP_001358840.1  mitogen-activated protein kinase kinase kinase 2

      Status: REVIEWED

      Source sequence(s)
      AC068282, AC110926
      Consensus CDS
      CCDS46404.1
      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
      Related
      ENSP00000387246.1, ENST00000409947.5
      Conserved Domains (2) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
    3. NM_006609.5NP_006600.3  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_006600.3

      Status: REVIEWED

      Source sequence(s)
      AC068282, AC110926
      Consensus CDS
      CCDS46404.1
      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
      Related
      ENSP00000343463.5, ENST00000344908.9
      Conserved Domains (2) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      127298668..127388465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442990.1XP_047298946.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
    2. XM_047442991.1XP_047298947.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
    3. XM_047442989.1XP_047298945.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      127733893..127823745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340218.1XP_054196193.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5
    2. XM_054340219.1XP_054196194.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3, Q9Y2U5