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    PRRG3 proline rich and Gla domain 3 [ Homo sapiens (human) ]

    Gene ID: 79057, updated on 28-Oct-2024

    Summary

    Official Symbol
    PRRG3provided by HGNC
    Official Full Name
    proline rich and Gla domain 3provided by HGNC
    Primary source
    HGNC:HGNC:30798
    See related
    Ensembl:ENSG00000130032 MIM:300685; AllianceGenome:HGNC:30798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMG3; PRGP3
    Summary
    This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in brain (RPKM 1.6), endometrium (RPKM 0.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRRG3 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (151694607..151705924)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (149962930..149974244)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150863079..150874396)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373367 Neighboring gene uncharacterized LOC105377213 Neighboring gene PAS domain containing repressor 1 Neighboring gene MPRA-validated peak7436 silencer Neighboring gene MPRA-validated peak7437 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21057 Neighboring gene fetal and adult testis expressed 1 Neighboring gene cyclic nucleotide gated channel subunit alpha 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149510, MGC156177

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 3
    Names
    proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
    proline-rich Gla protein 3
    proline-rich gamma-carboxyglutamic acid protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016589.2 RefSeqGene

      Range
      5853..16319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372163.1NP_001359092.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AF274854
      Consensus CDS
      CCDS14699.1
      UniProtKB/Swiss-Prot
      A1A523, A1A575, Q8N2N6, Q9BZD7
      Related
      ENSP00000501544.1, ENST00000674457.1
      Conserved Domains (1) summary
      pfam00594
      Location:2463
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    2. NM_001372165.1NP_001359094.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF274854
      Consensus CDS
      CCDS94688.1
      UniProtKB/TrEMBL
      A0A6I8PL69
      Related
      ENSP00000501402.1, ENST00000674441.1
      Conserved Domains (1) summary
      pfam00594
      Location:127
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    3. NM_024082.4NP_076987.3  transmembrane gamma-carboxyglutamic acid protein 3 isoform 1

      See identical proteins and their annotated locations for NP_076987.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AF274854, CD631899
      Consensus CDS
      CCDS14699.1
      UniProtKB/Swiss-Prot
      A1A523, A1A575, Q8N2N6, Q9BZD7
      Related
      ENSP00000440217.1, ENST00000538575.5
      Conserved Domains (1) summary
      pfam00594
      Location:2463
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    RNA

    1. NR_033262.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF274854, AK074574

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      151694607..151705924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      149962930..149974244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)