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    acdh-7 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 181758, updated on 2-Nov-2024

    Summary

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    Official Symbol
    acdh-7
    Official Full Name
    Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    Primary source
    WormBase:WBGene00020812
    Locus tag
    CELE_T25G12.5
    See related
    AllianceGenome:WB:WBGene00020812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in medium-chain fatty acid catabolic process. Predicted to be active in mitochondrion. Is expressed in anterior gonad arm; intestine; and pharynx. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See acdh-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (17215018..17217105, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Alpha-1,6-mannosyltransferase Neighboring gene putative medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial Neighboring gene ncRNA Neighboring gene Ras-related protein rab-6.2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection. Olaitan AO, et al. PLoS Genet, 2018 Sep. PMID 30265660, Free PMC Article
    2. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
    3. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
    4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    NP_510789.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17215018..17217105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078388.6 → NP_510789.1  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22781
      Conserved Domains (2) summary
      COG1960
      Location:24 → 408
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
      cl09933
      Location:28 → 405
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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