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    wee-1.1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1 [ Caenorhabditis elegans ]

    Gene ID: 192085, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wee-1.1
    Official Full Name
    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1
    Primary source
    WormBase:WBGene00006938
    Locus tag
    CELE_F35H8.7
    See related
    AllianceGenome:WB:WBGene00006938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including ABala; ABalp; E; Ea; and Ep. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See wee-1.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9581536..9583561, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene Putative UDP-glucuronosyltransferase ugt-58 Neighboring gene GTPase Era, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncoupling different characteristics of the C. elegans E lineage from differentiation of intestinal markers. Robertson SM, et al. PLoS One, 2014. PMID 25181289, Free PMC Article
    2. A Caenorhabditis elegans wee1 homolog is expressed in a temporally and spatially restricted pattern during embryonic development. Wilson MA, et al. Biochim Biophys Acta, 1999 Apr 14. PMID 10209262
    3. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Burrows AE, et al. Development, 2006 Feb. PMID 16421191, Free PMC Article
    4. A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death. Weidhaas JB, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16788064, Free PMC Article
    5. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1
    NP_496058.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9581536..9583561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063657.3 → NP_496058.1  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20085
      Conserved Domains (2) summary
      cd14050
      Location:104 → 354
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
      pfam00069
      Location:106 → 352
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20085.2

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