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    crebbpb CREB binding protein b [ Danio rerio (zebrafish) ]

    Gene ID: 567111, updated on 18-Sep-2024

    Summary

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    Official Symbol
    crebbpbprovided by ZNC
    Official Full Name
    CREB binding protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050302-102
    See related
    Ensembl:ENSDARG00000112452 AllianceGenome:ZFIN:ZDB-GENE-050302-102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CBP-A; Zfcbp; im:7150488; wu:fp53a03; gb:dq017638; si:ch211-121i18.1
    Summary
    Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Predicted to be involved in histone acetylation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated and rhythmic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in somite. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See crebbpb in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (9638767..9723341, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (9671380..9755745, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490435 Neighboring gene TNF receptor-associated protein 1 Neighboring gene adenylate cyclase type 9 Neighboring gene G2/M phase-specific E3 ubiquitin-protein ligase Neighboring gene uncharacterized LOC137490440

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Zhang B, et al. Mol Cell, 2018 Nov 15. PMID 30444999
    2. Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents. Kumari S, et al. J Neurosci Methods, 2020 Dec 1. PMID 32818549
    3. Expression patterns of CREB binding protein (CREBBP) and its methylated species during zebrafish development. Batut J, et al. Int J Dev Biol, 2015. PMID 26260685
    4. Epigenetic Regulators Modulate Muscle Damage in Duchenne Muscular Dystrophy Model. Bajanca F, et al. PLoS Curr, 2017 Dec 21. PMID 29399383, Free PMC Article
    5. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Pei DS, et al. Nucleic Acids Res, 2011 Apr. PMID 21172930, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CREB binding protein b
    Names
    CREBBPa
    NP_001352115.1
    XP_021328563.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365186.1 → NP_001352115.1  CREB binding protein b

      Status: VALIDATED

      Source sequence(s)
      BX957349, CR339059
      UniProtKB/TrEMBL
      A0A8M3B0Q0, A0A8M9PUL2
      Related
      ENSDARP00000140135.2, ENSDART00000168234.3
      Conserved Domains (10) summary
      cd05495
      Location:1021 → 1128
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd02337
      Location:1650 → 1690
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1140 → 1223
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1224 → 1258
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02172
      Location:550 → 630
      KIX; KIX domain
      pfam02135
      Location:338 → 405
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:1287 → 1594
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:2028 → 2125
      Creb_binding; Creb binding
      pfam09606
      Location:596 → 906
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:858 → 982
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      9638767..9723341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472888.2 → XP_021328563.1  CREB binding protein b isoform X1

      UniProtKB/TrEMBL
      A0A8M3B0Q0, A0A8M9PNF9
      Conserved Domains (10) summary
      cd05495
      Location:1021 → 1128
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd02337
      Location:1639 → 1679
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1140 → 1212
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1213 → 1247
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02172
      Location:550 → 630
      KIX; KIX domain
      pfam02135
      Location:338 → 405
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:1276 → 1583
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:2017 → 2114
      Creb_binding; Creb binding
      pfam09606
      Location:596 → 906
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:858 → 982
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394546.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      218220..302580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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