U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    acp2 acid phosphatase 2, lysosomal [ Danio rerio (zebrafish) ]

    Gene ID: 503759, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    acp2provided by ZNC
    Official Full Name
    acid phosphatase 2, lysosomalprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050306-40
    See related
    Ensembl:ENSDARG00000007244 AllianceGenome:ZFIN:ZDB-GENE-050306-40
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi35e03; wu:fi35e03; zgc:113200
    Summary
    The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. [provided by RefSeq, Dec 2017]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See acp2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39360781..39371386)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39089829..39100369)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene midkine a Neighboring gene cholinergic receptor, muscarinic 4a Neighboring gene autophagy/beclin-1 regulator 1a Neighboring gene solute carrier family 8 member B1 Neighboring gene troponin I type 2b (skeletal, fast), tandem duplicate 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
    2. An Adenosine Receptor for Olfaction in Fish. Wakisaka N, et al. Curr Biol, 2017 May 22. PMID 28502661
    3. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lysosomal acid phosphatase
    NP_001013355.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013337.2 → NP_001013355.1  lysosomal acid phosphatase precursor

      See identical proteins and their annotated locations for NP_001013355.1

      Status: REVIEWED

      Source sequence(s)
      BC090765, DY547619
      UniProtKB/TrEMBL
      Q5CZP5
      Related
      ENSDARP00000142979.1, ENSDART00000173481.2
      Conserved Domains (1) summary
      cd07061
      Location:22 → 322
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      39360781..39371386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001357187.1: Suppressed sequence

      Description
      NM_001357187.1: This RefSeq was removed because currently there is insufficient support for stop codon readthrough in this gene.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.