en2a engrailed homeobox 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: en2aprovided by ZNC
Official Full Name: engrailed homeobox 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-167
See related: Ensembl:ENSDARG00000026599 AllianceGenome:ZFIN:ZDB-GENE-980526-167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eng2; ENG-2; Zf-en; eng2a; ZF-EN-2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (40988910..40993456, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (40708837..40713383, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results demonstrate that the eng2a promoter integrates repressive and activating signals from the bone morphogenic protein and Hedgehog pathways
Title: Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome.

Submit: New GeneRIF Correction

General gene information

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Markers

eng2 (e-PCR)
- UniSTS:186950

Z13892 (e-PCR)
- UniSTS:204732

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis involved in innervation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein engrailed-2a

Names: engrailed 2a; homeobox protein en-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131044.2 → NP_571119.2 homeobox protein engrailed-2a

See identical proteins and their annotated locations for NP_571119.2

Status: VALIDATED

Source sequence(s)

CU041319

UniProtKB/Swiss-Prot

P09015

UniProtKB/TrEMBL

B3DGA1

Related

ENSDARP00000028905.4, ENSDART00000031700.6

Conserved Domains (2) summary

pfam00046
Location:179 → 232

Homeobox; Homeobox domain

pfam10525
Location:234 → 263

Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain