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    Ebi3 Epstein-Barr virus induced gene 3 [ Mus musculus (house mouse) ]

    Gene ID: 50498, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ebi3provided by MGI
    Official Full Name
    Epstein-Barr virus induced gene 3provided by MGI
    Primary source
    MGI:MGI:1354171
    See related
    Ensembl:ENSMUSG00000003206 AllianceGenome:MGI:1354171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBI-3; IL-27
    Summary
    Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 18.1), mammary gland adult (RPKM 10.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ebi3 in Genome Data Viewer
    Location:
    17 D; 17 29.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56259623..56264022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55952623..55957022)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene zinc finger protein 119b Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ebi3 knockout aggravates experimental periodontitis via Th17 polarization. Goto H, et al. J Clin Periodontol, 2023 Oct. PMID 37534736
    2. Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. Hausding M, et al. Eur J Immunol, 2007 Jun. PMID 17506035
    3. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Yang J, et al. Eur J Immunol, 2008 May. PMID 18412165, Free PMC Article
    4. Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice. Tong H, et al. Immunol Lett, 2010 Feb 16. PMID 20064562
    5. Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Zahn S, et al. Eur J Immunol, 2005 Apr. PMID 15756639

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
      Title: Ebi3 knockout aggravates experimental periodontitis via Th17 polarization.
    2. IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
      Title: IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3.
    3. Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
      Title: Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis.
    4. Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
      Title: Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.
    5. EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
      Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
    6. Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
      Title: Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
    7. This study evaluated changes in new and maintenance DNA methylation profiles in the liver after 55 days of infection with Schistosoma mansoni.
      Title: Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni.
    8. IL-35 subunits (EBI3 and p35), which are mainly expressed in regulatory T cells, were upregulated in mice after myocardial infarction. IL-35 reduces cardiac rupture, improves wound healing, and attenuates cardiac remodeling after MI by promoting reparative CX3CR1(+)Ly6C(low) macrophage survival.
      Title: Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice.
    9. we propose a novel mechanism for accumulating intracellular EBI3 and its regulation of macrophage apoptosis in response to virulent M. tb.
      Title: Accumulation of EBI3 induced by virulent Mycobacterium tuberculosis inhibits apoptosis in murine macrophages.
    10. In regulatory B cells, BATF, IFN regulatory factor, and IRF-8 transcription factors were recruited and bound to AP1-IRF-composite elements of il12a, ebi3, and/or il10 loci.
      Title: Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-27 receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-27 subunit beta
    Names
    IL-27 subunit beta
    IL-27B
    epstein-Barr virus-induced gene 3 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015766.2 → NP_056581.1  interleukin-27 subunit beta precursor

      See identical proteins and their annotated locations for NP_056581.1

      Status: VALIDATED

      Source sequence(s)
      AW495532, BI134394, BY134465, CX240802
      Consensus CDS
      CCDS28888.1
      UniProtKB/Swiss-Prot
      O35228
      UniProtKB/TrEMBL
      Q3U1K3
      Related
      ENSMUSP00000003274.7, ENSMUST00000003274.8
      Conserved Domains (1) summary
      cd00063
      Location:128 → 216
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56259623..56264022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524599.5 → XP_006524662.1  interleukin-27 subunit beta isoform X1

      Conserved Domains (1) summary
      cd00063
      Location:27 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35228.1 GenPept UniProtKB/Swiss-Prot:O35228

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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