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    Msrb2 methionine sulfoxide reductase B2 [ Mus musculus (house mouse) ]

    Gene ID: 76467, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Msrb2provided by MGI
    Official Full Name
    methionine sulfoxide reductase B2provided by MGI
    Primary source
    MGI:MGI:1923717
    See related
    Ensembl:ENSMUSG00000023094 AllianceGenome:MGI:1923717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrsb; Msrb; Pilb; 2310050L06Rik
    Summary
    Enables actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Involved in actin filament polymerization and protein repair. Located in mitochondrion. Is expressed in several structures, including brown fat; heart; inner ear; skeletal muscle; and testis. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 10.8), kidney adult (RPKM 6.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msrb2 in Genome Data Viewer
    Location:
    2 A3; 2 13.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (19376247..19399787)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (19371436..19394976)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E5893 Neighboring gene RIKEN cDNA 4930447M23 gene Neighboring gene STARR-seq mESC enhancer starr_03820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:19310470-19310705 Neighboring gene STARR-seq mESC enhancer starr_03823 Neighboring gene STARR-seq mESC enhancer starr_03825 Neighboring gene STARR-positive B cell enhancer ABC_E11703 Neighboring gene predicted gene, 33940 Neighboring gene predicted gene 13344 Neighboring gene pancreas specific transcription factor 1a, opposite strand Neighboring gene pancreas specific transcription factor, 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. Aachmann FL, et al. Proteins, 2011 Nov. PMID 21989933, Free PMC Article
    2. Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. Kim HY, et al. PLoS Biol, 2005 Dec. PMID 16262444, Free PMC Article
    3. Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology. Xiang XJ, et al. Exp Neurol, 2019 Aug. PMID 31078523
    4. Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Le DT, et al. Biochemistry, 2008 Jun 24. PMID 18505275, Free PMC Article
    5. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Kim HY, et al. Biochem Biophys Res Commun, 2004 Aug 6. PMID 15249228

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy.
      Title: Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
    2. the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible.
      Title: Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
    3. Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
      Title: Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
    4. overall structure is composed of two beta-sheets consisting of eight antiparallel beta-strands and three N-terminal alpha-helices and is more similar to those of bacterial MsrBs than to that of mammalian MsrB1
      Title: Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
    5. Studies show all Met sulfoxide residues in an MRP can be reduced by MsrA and MsrB.
      Title: Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
    6. MsrA and MsrB2, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies.
      Title: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
    7. Results show that mammalian MsrB and MsrA proteins perform crucial functions in protection against oxidative stress in lower eukaryotic yeast cells.
      Title: Expression, subcellular localization, and antioxidant role of mammalian methionine sulfoxide reductases in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine-R-sulfoxide reductase B2, mitochondrial
    Names
    pilin-like transcription factor
    NP_083895.1
    XP_006497626.1
    XP_017174809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029619.2 → NP_083895.1  methionine-R-sulfoxide reductase B2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083895.1

      Status: PROVISIONAL

      Source sequence(s)
      BC021619
      Consensus CDS
      CCDS15714.1
      UniProtKB/Swiss-Prot
      Q78J03
      Related
      ENSMUSP00000023856.9, ENSMUST00000023856.9
      Conserved Domains (1) summary
      PRK00222
      Location:43 → 172
      PRK00222; methionine sulfoxide reductase B; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      19376247..19399787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319320.2 → XP_017174809.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl15841
      Location:124 → 150
      SelR; SelR domain

    2. XM_006497563.3 → XP_006497626.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam01641
      Location:18 → 144
      SelR; SelR domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78J03.1 GenPept UniProtKB/Swiss-Prot:Q78J03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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