Camp cathelicidin antimicrobial peptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Campprovided by MGI
Official Full Name: cathelicidin antimicrobial peptideprovided by MGI
Primary source: MGI:MGI:108443
See related: Ensembl:ENSMUSG00000038357 AllianceGenome:MGI:108443
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLP; Cnlp; MCLP; CAP18; Cramp; FALL39
Summary: This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]
Expression: Biased expression in liver E18 (RPKM 317.5), liver E14.5 (RPKM 37.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (109676445..109678524, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (109847377..109849456, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and Myocardial Infarction in Mice and Human.
Title: Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and Myocardial Infarction in Mice and Human.
Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.
Title: Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.
LL-37 improves sepsis-induced acute lung injury by suppressing pyroptosis in alveolar epithelial cells.
Title: LL-37 improves sepsis-induced acute lung injury by suppressing pyroptosis in alveolar epithelial cells.
The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
Title: The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP.
Title: Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP.
Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation.
Title: Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation.
Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.
Title: Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
Title: A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.
Title: Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.
Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury.
Title: Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494120

Camp (e-PCR), detects polymorphism
- UniSTS:256602

Camp (e-PCR), detects polymorphism
- UniSTS:256603

NoName (e-PCR)
- UniSTS:484843

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-6	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptidoglycan	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in cytolysis	ISO Inferred from Sequence Orthology more info
involved_in cytolysis by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within killing by host of symbiont cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within killing by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in killing by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in modulation of process of another organism	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to yeast	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in specific granule	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cathelicidin antimicrobial peptide

Names: cathelin-like protein; cathelin-related antimicrobial peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009921.2 → NP_034051.2 cathelicidin antimicrobial peptide precursor

See identical proteins and their annotated locations for NP_034051.2

Status: REVIEWED

Source sequence(s)

BC120754, BY582734, U43409

Consensus CDS

CCDS52934.1

UniProtKB/Swiss-Prot

P51437, Q0VB78

UniProtKB/TrEMBL

Q3TZ97

Related

ENSMUSP00000107653.3, ENSMUST00000112022.5

Conserved Domains (2) summary

pfam00666
Location:29 → 95

Cathelicidins; Cathelicidin

pfam12153
Location:140 → 165

CAP18_C; LPS binding domain of CAP18 (C terminal)