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    Oasl1 2'-5' oligoadenylate synthetase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 231655, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Oasl1provided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase-like 1provided by MGI
    Primary source
    MGI:MGI:2180849
    See related
    Ensembl:ENSMUSG00000041827 AllianceGenome:MGI:2180849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    oasl9; 7530414C13Rik
    Summary
    Enables double-stranded RNA binding activity. Involved in interleukin-27-mediated signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in testis. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in small intestine adult (RPKM 38.2), stomach adult (RPKM 33.5) and 9 other tissues See more
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    Genomic context

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    See Oasl1 in Genome Data Viewer
    Location:
    5 F; 5 55.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115061236..115075970)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114923143..114937911)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase-like 2 Neighboring gene predicted gene 13822 Neighboring gene RIKEN cDNA 2210016L21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1057 Neighboring gene HNF1 homeobox A Neighboring gene HNF1 homeobox A, opposite strand 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway. Zhao W, et al. FASEB J, 2023 Mar. PMID 36809539
    2. OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis. Lee SA, et al. Nat Cell Biol, 2023 Jan. PMID 36604592, Free PMC Article
    3. OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses. Kang JS, et al. Mol Cells, 2018 Mar 31. PMID 29463066, Free PMC Article
    4. 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. Sim CK, et al. Cancer Immunol Immunother, 2016 Jun. PMID 27034232, Free PMC Article
    5. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Oh JE, et al. Sci Rep, 2016 Jan 11. PMID 26750802, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
      Title: OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
    2. results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
      Title: OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.
    3. these results show that OASL1 deficiency promotes the antitumor immune response, and thus, OASL1 could be a good therapeutic target for treating tumors.
      Title: 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons.
    4. OASL1 deficiency promotes antiviral immunity against local mucosal viral infection.
      Title: OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.
    5. Data from knockout mice suggest that Oasl1 is involved in regulation of innate immunity; Oasl1 knockout mice mount a better virus-specific CD8-positive T-cell response to lymphocytic choriomeningitis virus.
      Title: Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.
    6. OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.
      Title: OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase-like protein 1
    Names
    2',5'-oligoadenylate synthetase-like 9
    2,5-oligoadenylate synthetase-like 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359945.1 → NP_001346874.1  2'-5'-oligoadenylate synthase-like protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC117799, AK150863
      Consensus CDS
      CCDS19575.1
      UniProtKB/Swiss-Prot
      Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94
      Related
      ENSMUSP00000107771.4, ENSMUST00000112143.4
      Conserved Domains (4) summary
      cd05400
      Location:29 → 208
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam00240
      Location:432 → 498
      ubiquitin; Ubiquitin family
      pfam10421
      Location:165 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:350 → 429
      UBQ; Ubiquitin-like proteins

    2. NM_001359946.1 → NP_001346875.1  2'-5'-oligoadenylate synthase-like protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC117799
      Conserved Domains (3) summary
      pfam00240
      Location:253 → 319
      ubiquitin; Ubiquitin family
      pfam10421
      Location:9 → 168
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:171 → 250
      UBQ; Ubiquitin-like proteins

    3. NM_145209.3 → NP_660210.1  2'-5'-oligoadenylate synthase-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_660210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK078690
      Consensus CDS
      CCDS19575.1
      UniProtKB/Swiss-Prot
      Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94
      Related
      ENSMUSP00000031540.5, ENSMUST00000031540.11
      Conserved Domains (4) summary
      cd05400
      Location:29 → 208
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam00240
      Location:432 → 498
      ubiquitin; Ubiquitin family
      pfam10421
      Location:165 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:350 → 429
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115061236..115075970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530295.5 → XP_006530358.1  2'-5'-oligoadenylate synthase-like protein 1 isoform X1

      Conserved Domains (2) summary
      cd05400
      Location:29 → 208
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:165 → 215
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI94.1 GenPept UniProtKB/Swiss-Prot:Q8VI94

    Gene LinkOut

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