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    TCP11L1 t-complex 11 like 1 [ Homo sapiens (human) ]

    Gene ID: 55346, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TCP11L1provided by HGNC
    Official Full Name
    t-complex 11 like 1provided by HGNC
    Primary source
    HGNC:HGNC:25655
    See related
    Ensembl:ENSG00000176148 AllianceGenome:HGNC:25655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ85M6.3
    Summary
    Predicted to be involved in signal transduction. Located in microtubule. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.3), small intestine (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCP11L1 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33039572..33073563)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33175146..33209116)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33061118..33095109)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamine and serine rich 1 Neighboring gene uncharacterized LOC105376615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33022947-33023448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3230 Neighboring gene DEP domain containing 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33060521-33061068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:33071407-33071907 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33082368-33083567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33089797-33090298 Neighboring gene long intergenic non-protein coding RNA 294 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C pseudogene 1 Neighboring gene cleavage stimulation factor subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33181388-33182255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study of proneness to anger. Mick E, et al. PLoS One, 2014. PMID 24489884, Free PMC Article
    2. Host determinants of HIV-1 control in African Americans. Pelak K, et al. J Infect Dis, 2010 Apr 15. PMID 20205591, Free PMC Article
    3. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
    4. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article
    5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11336, FLJ11386

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-complex protein 11-like protein 1
    Names
    t-complex 11, testis-specific-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145541.1 → NP_001139013.1  T-complex protein 11-like protein 1

      See identical proteins and their annotated locations for NP_001139013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131263, AK002198, BP281502, DA340843
      Consensus CDS
      CCDS7882.1
      UniProtKB/Swiss-Prot
      D3DR01, Q8IVX4, Q9NUJ3
      UniProtKB/TrEMBL
      B3KQZ4
      Related
      ENSP00000395070.1, ENST00000432887.5
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 502
      Tcp11; T-complex protein 11

    2. NM_018393.4 → NP_060863.3  T-complex protein 11-like protein 1

      See identical proteins and their annotated locations for NP_060863.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131263, AK090646, BP281502, DA088926
      Consensus CDS
      CCDS7882.1
      UniProtKB/Swiss-Prot
      D3DR01, Q8IVX4, Q9NUJ3
      UniProtKB/TrEMBL
      B3KQZ4
      Related
      ENSP00000335595.4, ENST00000334274.9
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 502
      Tcp11; T-complex protein 11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      33039572..33073563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520207.3 → XP_011518509.1  T-complex protein 11-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011518509.1

      UniProtKB/Swiss-Prot
      D3DR01, Q8IVX4, Q9NUJ3
      UniProtKB/TrEMBL
      B3KQZ4
      Related
      ENSP00000433067.1, ENST00000531632.6
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 502
      Tcp11; T-complex protein 11

    2. XM_017017989.3 → XP_016873478.1  T-complex protein 11-like protein 1 isoform X1

      UniProtKB/TrEMBL
      B3KQZ4
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 505
      Tcp11; T-complex protein 11

    3. XM_047427237.1 → XP_047283193.1  T-complex protein 11-like protein 1 isoform X4

    4. XM_011520205.3 → XP_011518507.1  T-complex protein 11-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011518507.1

      UniProtKB/TrEMBL
      B3KQZ4
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 505
      Tcp11; T-complex protein 11

    5. XM_017017990.2 → XP_016873479.1  T-complex protein 11-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      D3DR01, Q8IVX4, Q9NUJ3
      UniProtKB/TrEMBL
      B3KQZ4
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 502
      Tcp11; T-complex protein 11

    6. XM_011520206.3 → XP_011518508.1  T-complex protein 11-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011518508.1

      UniProtKB/TrEMBL
      B3KQZ4
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 505
      Tcp11; T-complex protein 11

    7. XM_011520204.3 → XP_011518506.1  T-complex protein 11-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011518506.1

      UniProtKB/TrEMBL
      B3KQZ4
      Conserved Domains (1) summary
      pfam05794
      Location:78 → 505
      Tcp11; T-complex protein 11

    8. XM_047427236.1 → XP_047283192.1  T-complex protein 11-like protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      33175146..33209116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369299.1 → XP_054225274.1  T-complex protein 11-like protein 1 isoform X1

    2. XM_054369307.1 → XP_054225282.1  T-complex protein 11-like protein 1 isoform X4

    3. XM_054369304.1 → XP_054225279.1  T-complex protein 11-like protein 1 isoform X2

    4. XM_054369303.1 → XP_054225278.1  T-complex protein 11-like protein 1 isoform X2

    5. XM_054369300.1 → XP_054225275.1  T-complex protein 11-like protein 1 isoform X1

    6. XM_054369301.1 → XP_054225276.1  T-complex protein 11-like protein 1 isoform X1

    7. XM_054369302.1 → XP_054225277.1  T-complex protein 11-like protein 1 isoform X1

    8. XM_054369305.1 → XP_054225280.1  T-complex protein 11-like protein 1 isoform X5

    9. XM_054369306.1 → XP_054225281.1  T-complex protein 11-like protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUJ3.1 GenPept UniProtKB/Swiss-Prot:Q9NUJ3

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