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    ZNF669 zinc finger protein 669 [ Homo sapiens (human) ]

    Gene ID: 79862, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF669provided by HGNC
    Official Full Name
    zinc finger protein 669provided by HGNC
    Primary source
    HGNC:HGNC:25736
    See related
    Ensembl:ENSG00000188295 AllianceGenome:HGNC:25736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 3.0), testis (RPKM 2.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF669 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247099962..247104356, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246531595..246535990, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247263264..247267658, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247208766-247208933 Neighboring gene zinc finger protein 670 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247241976-247242289 Neighboring gene Sharpr-MPRA regulatory region 11854 Neighboring gene uncharacterized LOC400812 Neighboring gene long intergenic non-protein coding RNA 2897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells. Makarov A, et al. Cell Biol Int, 2013 Oct. PMID 23686814
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12606

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 669

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142572.2 → NP_001136044.1  zinc finger protein 669 isoform 2

      See identical proteins and their annotated locations for NP_001136044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) that lacks a segment of the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK056020, CA447495
      Consensus CDS
      CCDS44345.1
      UniProtKB/Swiss-Prot
      Q96BR6
      Related
      ENSP00000404370.2, ENST00000448299.7
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:92 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:178 → 202
      zf-H2C2_2; Zinc-finger double domain

    2. NM_024804.3 → NP_079080.2  zinc finger protein 669 isoform 1

      See identical proteins and their annotated locations for NP_079080.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL627095, BC015312, CA447495
      Consensus CDS
      CCDS31088.1
      UniProtKB/Swiss-Prot
      B3KP94, Q5VT39, Q96BR6, Q9H9Q6
      Related
      ENSP00000342818.6, ENST00000343381.10
      Conserved Domains (5) summary
      smart00349
      Location:90 → 132
      KRAB; krueppel associated box
      COG5048
      Location:178 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:90 → 129
      KRAB; KRAB box
      pfam13465
      Location:264 → 288
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      247099962..247104356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      246531595..246535990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BR6.2 GenPept UniProtKB/Swiss-Prot:Q96BR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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