RNASE12 ribonuclease A family member 12 (inactive) [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNASE12provided by HGNC
Official Full Name: ribonuclease A family member 12 (inactive)provided by HGNC
Primary source: HGNC:HGNC:24211
See related: Ensembl:ENSG00000258436 AllianceGenome:HGNC:24211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAI1; HEL-S-85p
Summary: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (20590073..20591376, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (14787199..14788502, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (21058232..21059535, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable inactive ribonuclease-like protein 12

Names: epididymis secretory sperm binding protein Li 85p; ribonuclease A I1; ribonuclease, RNase A family, 12 (non-active); ribonuclease-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024822.4 → NP_001019993.1 probable inactive ribonuclease-like protein 12 precursor

See identical proteins and their annotated locations for NP_001019993.1

Status: VALIDATED

Source sequence(s)

AL163195

Consensus CDS

CCDS32037.1

UniProtKB/Swiss-Prot

Q5GAN4

UniProtKB/TrEMBL

W0UV30

Related

ENSP00000512867.1, ENST00000696784.1

Conserved Domains (1) summary

cd00163
Location:24 → 143

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...