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    DPP7 dipeptidyl peptidase 7 [ Homo sapiens (human) ]

    Gene ID: 29952, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DPP7provided by HGNC
    Official Full Name
    dipeptidyl peptidase 7provided by HGNC
    Primary source
    HGNC:HGNC:14892
    See related
    Ensembl:ENSG00000176978 MIM:610537; AllianceGenome:HGNC:14892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QPP; DPP2; DPPII
    Summary
    The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DPP7 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137110546..137118306, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149348484..149356230, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140004998..140009185, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene small nucleolar RNA SNORD62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29344 Neighboring gene uncharacterized LOC124902313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20581 Neighboring gene uncharacterized LOC124902314 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20583 Neighboring gene Sharpr-MPRA regulatory region 8071 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29346 Neighboring gene uncharacterized LOC105376328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells. Fornas E, et al. Histol Histopathol, 1992 Apr. PMID 1515698
    2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. Underwood R, et al. J Biol Chem, 1999 Nov 26. PMID 10567372
    3. Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats. Zhan H, et al. Histochem J, 2001 Sep-Oct. PMID 12005022
    4. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. Chiravuri M, et al. J Immunol, 1999 Sep 15. PMID 10477574
    5. Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases. Demuth HU, et al. FEBS Lett, 1993 Mar 29. PMID 8096464

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. human DPP7 structures reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases
      Title: Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.
    2. The constitutive expression of dipeptidyl peptidase II mRNA in chronic lymphocytic leukemia was demonstrated.
      Title: Expression and prognostic assessment of dipeptidyl peptidase IV and related enzymes in B-cell chronic lymphocytic leukemia.
    3. DPP2 is essential for maintaining lymphocytes and fibroblasts in G(0), and its inhibition results in apoptosis mediated by induction of c-Myc and p53.
      Title: Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence.
    4. DPP II plays a minor role in the progression of malignant melanocytic lesions
      Title: Dipeptidyl peptidase II is not a marker for progression in melanoma.
    5. catalytic properties and inhibition of this proline-specific enzyme
      Title: Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lysosomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl peptidase 2
    Names
    DPP II
    carboxytripeptidase
    dipeptidyl aminopeptidase II
    dipeptidyl arylamidase II
    dipeptidyl-peptidase II
    quiescent cell proline dipeptidase
    NP_037511.2
    XP_011516901.1
    XP_011516902.1
    XP_016870140.1
    XP_016870141.1
    XP_047279236.1
    XP_047279237.1
    XP_054218802.1
    XP_054218803.1
    XP_054218804.1
    XP_054218805.1
    XP_054218806.1
    XP_054218807.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013379.3 → NP_037511.2  dipeptidyl peptidase 2 preproprotein

      See identical proteins and their annotated locations for NP_037511.2

      Status: REVIEWED

      Source sequence(s)
      AF154502, AL533195, BC016961, BX400716
      Consensus CDS
      CCDS7030.1
      UniProtKB/Swiss-Prot
      A8K7U7, Q5VSF1, Q969X4, Q9UHL4
      Related
      ENSP00000360635.2, ENST00000371579.7
      Conserved Domains (1) summary
      cl21494
      Location:38 → 465
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      137110546..137118306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423281.1 → XP_047279237.1  dipeptidyl peptidase 2 isoform X6

    2. XM_011518600.2 → XP_011516902.1  dipeptidyl peptidase 2 isoform X2

      Related
      ENST00000706880.1
      Conserved Domains (1) summary
      cl21494
      Location:56 → 457
      Abhydrolase; alpha/beta hydrolases

    3. XM_017014652.3 → XP_016870141.1  dipeptidyl peptidase 2 isoform X5

      Related
      ENSP00000520771.1, ENST00000718334.1

    4. XM_017014651.2 → XP_016870140.1  dipeptidyl peptidase 2 isoform X3

    5. XM_011518599.3 → XP_011516901.1  dipeptidyl peptidase 2 isoform X1

      Related
      ENST00000478597.6
      Conserved Domains (1) summary
      cl21494
      Location:86 → 487
      Abhydrolase; alpha/beta hydrolases

    6. XM_047423280.1 → XP_047279236.1  dipeptidyl peptidase 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149348484..149356230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362832.1 → XP_054218807.1  dipeptidyl peptidase 2 isoform X6

    2. XM_054362828.1 → XP_054218803.1  dipeptidyl peptidase 2 isoform X2

    3. XM_054362827.1 → XP_054218802.1  dipeptidyl peptidase 2 isoform X1

    4. XM_054362829.1 → XP_054218804.1  dipeptidyl peptidase 2 isoform X3

    5. XM_054362830.1 → XP_054218805.1  dipeptidyl peptidase 2 isoform X4

    6. XM_054362831.1 → XP_054218806.1  dipeptidyl peptidase 2 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHL4.3 GenPept UniProtKB/Swiss-Prot:Q9UHL4

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