U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NME2 NME/NM23 nucleoside diphosphate kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4831, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NME2provided by HGNC
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:7850
    See related
    Ensembl:ENSG00000243678 MIM:156491; AllianceGenome:HGNC:7850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
    Summary
    Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NME2 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (51165536..51171744)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (52032848..52039047)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49242897..49249105)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49175960-49176460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12398 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:49198151-49198965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12400 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:49205455-49205678 Neighboring gene MPRA-validated peak2888 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr17:49219886-49220387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49222416-49222916 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:49230233-49231432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49232587-49233118 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:49243725-49244333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8725 Neighboring gene NME1-NME2 readthrough Neighboring gene MPRA-validated peak2890 silencer Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene mbt domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12402 Neighboring gene UTP18 small subunit processome component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12403 Neighboring gene NANOG hESC enhancer GRCh37_chr17:49408132-49408651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49409544-49410044 Neighboring gene long intergenic non-protein coding RNA 2071

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis. Liu YF, et al. PLoS One, 2015. PMID 25700270, Free PMC Article
    2. Measurement of human breast tumor cell-secreted shNDPK-B in a murine breast cancer model suggests its role in metastatic progression. Yokdang N, et al. Proc West Pharmacol Soc, 2009. PMID 20830314, Free PMC Article
    3. The human NME2 gene lies within 18kb of NME1 in chromosome 17. Chandrasekharappa SC, et al. Genes Chromosomes Cancer, 1993 Apr. PMID 7685630
    4. Bcr-Abl dependent post-transcriptional activation of NME2 expression is a specific and common feature of chronic myeloid leukemia. Tschiedel S, et al. Leuk Lymphoma, 2012 Aug. PMID 22251158
    5. Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit. Pinon VP, et al. Exp Cell Res, 1999 Feb 1. PMID 9925751

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
      Title: Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
    2. Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
      Title: Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
    3. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
      Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
    4. The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
      Title: The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
    5. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
      Title: Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
    6. NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
      Title: NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
    7. miR-645 was up-regulated in osteosarcoma tissues and could promote osteosarcoma cell migration through directly inhibiting the tumor suppressor NME2
      Title: MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2.
    8. Study in cultured HUVEC cells demonstrated that the upregulation of ANG2 upon NDPK-B deficiency (siRNA knockdown) is driven by O-GlcNAcylation of FOXO1 and provide evidence for a central role of protein O-GlcNAcylation in NDPK-B associated vascular damage and point to the hexosamine pathway as an important target in retinal vasoregression.
      Title: O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage.
    9. Study reports that NME2 is an oncogene in osteosarcoma (OS) that is associated with its clinicopathologic features. Downregulation of NME2 could reduce the proliferation of OS cells and arrest the OS cell cycle in the G2/M phase. The deregulation of NME2 enhanced the expression of c-Myc and affected the proliferation of osteosarcoma.
      Title: Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc.
    10. NME2 mediates chemoresistance to 5-FU in CRC
      Title: Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of NME/NM23 nucleoside diphosphate kinase 2 (NME2) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC2212, MGC111212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside triphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-histidine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    NOT located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nucleoside diphosphate kinase B
    Names
    HEL-S-155an
    NDP kinase B
    c-myc purine-binding transcription factor PUF
    c-myc transcription factor
    epididymis secretory sperm binding protein Li 155an
    histidine protein kinase NDKB
    non-metastatic cells 2, protein (NM23) expressed in
    non-metastatic cells 2, protein (NM23B) expressed in
    nucleotide diphosphate kinase B
    NP_001018147.1
    NP_001018148.1
    NP_001018149.1
    NP_001185611.1
    NP_002503.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018137.3 → NP_001018147.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      CA307456, CK023920
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000426976.2, ENST00000514264.6
      Conserved Domains (1) summary
      PTZ00093
      Location:3 → 151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    2. NM_001018138.1 → NP_001018148.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018148.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC002476, BF058708
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000376886.1, ENST00000393190.4
      Conserved Domains (1) summary
      PTZ00093
      Location:3 → 151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    3. NM_001018139.2 → NP_001018149.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_001018149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BM556410
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000426901.1, ENST00000503064.5
      Conserved Domains (1) summary
      PTZ00093
      Location:3 → 151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    4. NM_001198682.2 → NP_001185611.1  nucleoside diphosphate kinase B isoform b

      See identical proteins and their annotated locations for NP_001185611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      CB242387, CN267160, DB454073
      Consensus CDS
      CCDS74107.1
      UniProtKB/TrEMBL
      F6XY72
      Related
      ENSP00000376880.4, ENST00000393183.7
      Conserved Domains (1) summary
      cl00335
      Location:5 → 76
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

    5. NM_002512.4 → NP_002503.1  nucleoside diphosphate kinase B isoform a

      See identical proteins and their annotated locations for NP_002503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.
      Source sequence(s)
      BC095458, BF034471, DB454073
      Consensus CDS
      CCDS11580.1
      UniProtKB/Swiss-Prot
      A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
      UniProtKB/TrEMBL
      Q6FHN3
      Related
      ENSP00000421064.1, ENST00000512737.6
      Conserved Domains (1) summary
      PTZ00093
      Location:3 → 151
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      51165536..51171744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      52032848..52039047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22392.1 GenPept UniProtKB/Swiss-Prot:P22392

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous