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    FBXO21 F-box protein 21 [ Homo sapiens (human) ]

    Gene ID: 23014, updated on 28-Oct-2024

    Summary

    Official Symbol
    FBXO21provided by HGNC
    Official Full Name
    F-box protein 21provided by HGNC
    Primary source
    HGNC:HGNC:13592
    See related
    Ensembl:ENSG00000135108 MIM:609095; AllianceGenome:HGNC:13592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX21
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 31.4), ovary (RPKM 26.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FBXO21 in Genome Data Viewer
    Location:
    12q24.22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (117141991..117190470, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (117123006..117171512, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (117579796..117628275, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117477181-117478126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117478127-117479070 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117479989-117480493 Neighboring gene Sharpr-MPRA regulatory region 12461 Neighboring gene Sharpr-MPRA regulatory region 12935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117490883-117491488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117492095-117492700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117500995-117501771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117500218-117500994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4911 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117537215-117537353 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117538220-117538437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117540353-117540852 Neighboring gene uncharacterized LOC105370010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117556298-117556892 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:117580597-117581796 Neighboring gene tescalcin Neighboring gene TESC antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117645205-117645705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:117657550-117658106 Neighboring gene MPRA-validated peak1985 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:117670646-117670812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674186-117674690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117674691-117675195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:117718941-117719440 Neighboring gene nitric oxide synthase 1 Neighboring gene elongin C pseudogene 32 Neighboring gene NOS1 1f and 1g alternate promoter region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:117826376-117826876 Neighboring gene NOS1 1c alternate promoter Neighboring gene uncharacterized LOC105370012 Neighboring gene kinase suppressor of ras 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of F-box protein 21 (FBXO21) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90233, KIAA0875, MGC26682, DKFZp434G058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015002.3NP_055817.1  F-box only protein 21 isoform 2

      See identical proteins and their annotated locations for NP_055817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 21 nt fragment within the coding region, and thus encodes a 7 aa shorter isoform than variant 1.
      Source sequence(s)
      AB020682, AC026368, BC034045, BC042333, BI550121
      Consensus CDS
      CCDS44989.1
      UniProtKB/TrEMBL
      Q4G104
      Related
      ENSP00000483508.1, ENST00000622495.5
      Conserved Domains (3) summary
      TIGR02097
      Location:493590
      yccV; hemimethylated DNA binding domain
      smart00256
      Location:3374
      FBOX; A Receptor for Ubiquitination Targets
      pfam13369
      Location:215388
      Transglut_core2; Transglutaminase-like superfamily
    2. NM_033624.3NP_296373.1  F-box only protein 21 isoform 1

      See identical proteins and their annotated locations for NP_296373.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an additional 21 nt fragment within the coding region, and thus encodes a 7 aa longer isoform than variant 2.
      Source sequence(s)
      AB020682, AC026368, AL136899, BC034045, BC042333, BI550121
      Consensus CDS
      CCDS9184.1
      UniProtKB/Swiss-Prot
      B3KMF0, O94952, Q5BJG0, Q9H087
      UniProtKB/TrEMBL
      Q4G104
      Related
      ENSP00000328187.5, ENST00000330622.9
      Conserved Domains (3) summary
      TIGR02097
      Location:500597
      yccV; hemimethylated DNA binding domain
      smart00256
      Location:3374
      FBOX; A Receptor for Ubiquitination Targets
      pfam13369
      Location:215388
      Transglut_core2; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      117141991..117190470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019038.3XP_016874527.1  F-box only protein 21 isoform X2

      UniProtKB/TrEMBL
      H0YIE9
      Related
      ENSP00000449264.1, ENST00000550180.5
      Conserved Domains (3) summary
      TIGR02097
      Location:433530
      yccV; hemimethylated DNA binding domain
      smart00256
      Location:3374
      FBOX; A Receptor for Ubiquitination Targets
      COG2912
      Location:252331
      SirB1; Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms]
    2. XM_017019037.3XP_016874526.1  F-box only protein 21 isoform X1

      UniProtKB/TrEMBL
      H0YIE9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      117123006..117171512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371465.1XP_054227440.1  F-box only protein 21 isoform X2

    2. XM_054371464.1XP_054227439.1  F-box only protein 21 isoform X1