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    EXOC6B exocyst complex component 6B [ Homo sapiens (human) ]

    Gene ID: 23233, updated on 28-Oct-2024

    Summary

    Official Symbol
    EXOC6Bprovided by HGNC
    Official Full Name
    exocyst complex component 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:17085
    See related
    Ensembl:ENSG00000144036 MIM:607880; AllianceGenome:HGNC:17085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC15B; SEC15L2; SEMDJL3
    Summary
    This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016]
    Expression
    Ubiquitous expression in heart (RPKM 12.8), brain (RPKM 8.7) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EXOC6B in Genome Data Viewer
    Location:
    2p13.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (72175984..72826033, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (72189067..72838971, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (72403113..73053162, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72239996-72240496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72240497-72240997 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:72248010-72248658 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:72248659-72249307 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:72258545-72259744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72263893-72264560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72312423-72312923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72332215-72332714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72355065-72355844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72362955-72363918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:72365847-72366810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72373667-72374189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72374379-72374880 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:72378306-72378481 Neighboring gene cytochrome P450 family 26 subfamily B member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:72463389-72463890 Neighboring gene ribosomal protein S15a pseudogene 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:72773139-72773380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72865570-72866299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72866300-72867028 Neighboring gene Sharpr-MPRA regulatory region 2924 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:72978191-72979035 Neighboring gene small nucleolar RNA SNORD78 Neighboring gene RNA, U2 small nuclear 39, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72999013-72999514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:72999515-73000014 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:73052157-73052667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11625 Neighboring gene zinc finger MYM-type containing 1 pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr2.2721 Neighboring gene VISTA enhancer hs1025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:73119309-73119810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:73115417-73115591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11626 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:73110580-73110740 Neighboring gene sepiapterin reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0919, WUGSC:H_NH0343N14.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    exocyst complex component 6B
    Names
    SEC15 homolog B
    SEC15-like protein 2
    exocyst complex component Sec15B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050967.1 RefSeqGene

      Range
      5016..655065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321729.2NP_001308658.1  exocyst complex component 6B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
      Consensus CDS
      CCDS82468.1
      UniProtKB/TrEMBL
      A0A0U1RRB6, J3QT38
      Related
      ENSP00000489442.1, ENST00000634650.1
      Conserved Domains (1) summary
      pfam04091
      Location:465771
      Sec15; Exocyst complex subunit Sec15-like
    2. NM_001321730.2NP_001308659.1  exocyst complex component 6B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
      Conserved Domains (1) summary
      pfam04091
      Location:465726
      Sec15; Exocyst complex subunit Sec15-like
    3. NM_001321731.2NP_001308660.1  exocyst complex component 6B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
      UniProtKB/TrEMBL
      J3QT38
      Conserved Domains (1) summary
      pfam04091
      Location:465771
      Sec15; Exocyst complex subunit Sec15-like
    4. NM_001321733.2NP_001308662.1  exocyst complex component 6B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
      UniProtKB/TrEMBL
      J3QT38
      Conserved Domains (1) summary
      pfam04091
      Location:465726
      Sec15; Exocyst complex subunit Sec15-like
    5. NM_001321734.2NP_001308663.1  exocyst complex component 6B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
      Conserved Domains (1) summary
      pfam04091
      Location:352658
      Sec15; Exocyst complex subunit Sec15-like
    6. NM_015189.3NP_056004.1  exocyst complex component 6B isoform 2

      See identical proteins and their annotated locations for NP_056004.1

      Status: REVIEWED

      Source sequence(s)
      AB023136, AC006461, AC092630, AK026474, BM995822
      Consensus CDS
      CCDS46333.1
      UniProtKB/Swiss-Prot
      B8ZZY3, Q9Y2D4
      UniProtKB/TrEMBL
      J3QT38
      Related
      ENSP00000272427.7, ENST00000272427.11
      Conserved Domains (1) summary
      pfam04091
      Location:465771
      Sec15; Exocyst complex subunit Sec15-like

    RNA

    1. NR_135773.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822
    2. NR_135774.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006461, AC016770, AC092630, AC104309, AC105051, BM995822

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      72175984..72826033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003642.2XP_016859131.1  exocyst complex component 6B isoform X3

      Conserved Domains (1) summary
      pfam04091
      Location:133439
      Sec15; Exocyst complex subunit Sec15-like
    2. XM_005264224.2XP_005264281.1  exocyst complex component 6B isoform X3

      Conserved Domains (1) summary
      pfam04091
      Location:133439
      Sec15; Exocyst complex subunit Sec15-like
    3. XM_011532711.4XP_011531013.1  exocyst complex component 6B isoform X1

      UniProtKB/TrEMBL
      J3QT38
      Conserved Domains (1) summary
      pfam04091
      Location:465660
      Sec15; Exocyst complex subunit Sec15-like
    4. XM_011532712.4XP_011531014.1  exocyst complex component 6B isoform X2

      UniProtKB/TrEMBL
      J3QT38
      Related
      ENSP00000386698.1, ENST00000410104.1
      Conserved Domains (1) summary
      pfam04091
      Location:465662
      Sec15; Exocyst complex subunit Sec15-like

    RNA

    1. XR_007071495.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      72189067..72838971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341081.1XP_054197056.1  exocyst complex component 6B isoform X3

    2. XM_054341082.1XP_054197057.1  exocyst complex component 6B isoform X3

    3. XM_054341079.1XP_054197054.1  exocyst complex component 6B isoform X1

    4. XM_054341080.1XP_054197055.1  exocyst complex component 6B isoform X2

    RNA

    1. XR_008486308.1 RNA Sequence