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    HSP90AA4P heat shock protein 90 alpha family class A member 4, pseudogene [ Homo sapiens (human) ]

    Gene ID: 3323, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HSP90AA4Pprovided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 4, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:5255
    See related
    AllianceGenome:HGNC:5255
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP90Ad; HSPCAL2
    Summary
    Predicted to enable ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including myelin sheath; neuronal cell body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HSP90AA4P in Genome Data Viewer
    Location:
    4q35.2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (189472906..189475853)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (192829528..192832472)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (190394060..190397007)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900838 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190229364-190230563 Neighboring gene uncharacterized LOC105377614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:190400698-190401256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:190405217-190405972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:190405973-190406728 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190471799-190472998 Neighboring gene uncharacterized LOC105377615 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:190523074-190524273 Neighboring gene long intergenic non-protein coding RNA 1262

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. Ozawa K, et al. Genomics, 1992 Feb. PMID 1740332
    2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen B, et al. Genomics, 2005 Dec. PMID 16269234
    3. α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation. Borutinskaite VV, et al. Mol Biol Rep, 2011 Jun. PMID 20111909
    4. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Beyer T, et al. Mol Cell Proteomics, 2018 Jul. PMID 29615496, Free PMC Article
    5. METTL3 protects METTL14 from STUB1-mediated degradation to maintain m(6) A homeostasis. Zeng ZC, et al. EMBO Rep, 2023 Mar 6. PMID 36597993, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • heat shock 90kD protein 1, alpha-like 2
    • heat shock 90kDa protein 1, alpha-like 2
    • heat shock protein 90Ad
    • heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene
    • heat shock protein 90kDa alpha family class A member 4, pseudogene

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_003014.3 

      Range
      101..3048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      189472906..189475853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_187679.1 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      111049..113996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      192829528..192832472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_036692.1: Suppressed sequence

      Description
      NR_036692.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58FG1.1 GenPept UniProtKB/Swiss-Prot:Q58FG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.