Ccr2 C-C motif chemokine receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr2provided by MGI
Official Full Name: C-C motif chemokine receptor 2provided by MGI
Primary source: MGI:MGI:106185
See related: Ensembl:ENSMUSG00000049103 AllianceGenome:MGI:106185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2
Summary: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including mononuclear cell migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 3.5), mammary gland adult (RPKM 3.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 75.05 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123901954..123913594)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (124101918..124109140)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking.
Title: STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking.
Ccr2-dependent monocytes exacerbate intestinal inflammation and modulate gut serotonergic signaling following traumatic brain injury.
Title: Ccr2-dependent monocytes exacerbate intestinal inflammation and modulate gut serotonergic signaling following traumatic brain injury.
CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow.
Title: CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow.
Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation.
Title: Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation.
CCR2[+] monocytes/macrophages drive steroid hormone imbalance-related prostatic fibrosis.
Title: CCR2(+) monocytes/macrophages drive steroid hormone imbalance-related prostatic fibrosis.
The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.
Title: The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.
C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain.
Title: C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain.
Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2.
Title: Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2.
Chronic pain accelerates cognitive impairment by reducing hippocampal neurogenesis may via CCL2/CCR2 signaling in APP/PS1 mice.
Title: Chronic pain accelerates cognitive impairment by reducing hippocampal neurogenesis may via CCL2/CCR2 signaling in APP/PS1 mice.
Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling.
Title: Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (349)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (14) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC228408P2 (e-PCR)
- UniSTS:272155

Cmkbr2 (e-PCR), detects polymorphism
- UniSTS:141357

PMC164693P1 (e-PCR)
- UniSTS:271512

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables CCR2 chemokine receptor binding	IEA Inferred from Electronic Annotation more info
enables chemokine (C-C motif) ligand 12 binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine (C-C motif) ligand 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine (C-C motif) ligand 5 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 7 binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic cell clearance	IC Inferred by Curator more info	PubMed
involved_in blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eosinophil degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CD8-positive, alpha-beta T cell extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of astrocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immune complex clearance by monocytes and macrophages	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of thymocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mononuclear cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing involved in inflammatory response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in primary dendrite	IEA Inferred from Electronic Annotation more info
located_in primary dendrite	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 2

Names: C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; CCR-2; JE/FIC receptor; MCP-1 receptor; MIP-1 alphaR; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009915.2 → NP_034045.1 C-C chemokine receptor type 2

See identical proteins and their annotated locations for NP_034045.1

Status: VALIDATED

Source sequence(s)

AK138599, AK162705, U56819

Consensus CDS

CCDS23669.1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Related

ENSMUSP00000049909.7, ENSMUST00000055918.7

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

123901954..123913594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154587.1 → XP_036010480.1 C-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Related

ENSMUSP00000130112.2, ENSMUST00000171719.8

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011243063.2 → XP_011241365.1 C-C chemokine receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_011241365.1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036154586.1 → XP_036010479.1 C-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036154585.1 → XP_036010478.1 C-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011243064.4 → XP_011241366.1 C-C chemokine receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_011241366.1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Related

ENSMUSP00000132453.2, ENSMUST00000168841.3

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006512428.3 → XP_006512491.1 C-C chemokine receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_006512491.1

UniProtKB/Swiss-Prot

P51683, Q61172

UniProtKB/TrEMBL

Q543S8

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors