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    OSGIN2 oxidative stress induced growth inhibitor family member 2 [ Homo sapiens (human) ]

    Gene ID: 734, updated on 14-Nov-2024

    Summary

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    Official Symbol
    OSGIN2provided by HGNC
    Official Full Name
    oxidative stress induced growth inhibitor family member 2provided by HGNC
    Primary source
    HGNC:HGNC:1355
    See related
    Ensembl:ENSG00000164823 MIM:604598; AllianceGenome:HGNC:1355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hT41; C8orf1
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 10.6), brain (RPKM 9.0) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See OSGIN2 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (89901868..89927888)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91025051..91051069)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90914096..90940116)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27606 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27607 Neighboring gene MPRA-validated peak7104 silencer Neighboring gene Sharpr-MPRA regulatory region 7187 Neighboring gene uncharacterized LOC124901974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90912677-90913442 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90913443-90914208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19347 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:90914502-90914800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19348 Neighboring gene RNA, U6 small nuclear 925, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90959982-90961181 Neighboring gene nibrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90996459-90997255 Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27611 Neighboring gene 2,4-dienoyl-CoA reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. Tauchi H, et al. Genomics, 1999 Jan 15. PMID 9933573
    2. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Bailey ML, et al. Genetics, 2015 Nov. PMID 26354767, Free PMC Article
    3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-induced growth inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126111.3 → NP_001119583.1  oxidative stress-induced growth inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001119583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5'UTR that includes a translation start site that is upstream and in-frame with that used for variant 2. The resulting protein (isoform 1) is longer and has a distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AF061326, BC031054, BM764021, BU739360
      Consensus CDS
      CCDS47888.1
      UniProtKB/Swiss-Prot
      Q9Y236
      Related
      ENSP00000396445.2, ENST00000451899.7
      Conserved Domains (1) summary
      cl21454
      Location:217 → 363
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_004337.2 → NP_004328.1  oxidative stress-induced growth inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_004328.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'UTR resulting in translation initiation from an internal AUG site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AF061326, BC031054, BU688773
      Consensus CDS
      CCDS6248.1
      UniProtKB/Swiss-Prot
      Q9Y236
      Related
      ENSP00000297438.2, ENST00000297438.6
      Conserved Domains (1) summary
      cl21454
      Location:173 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      89901868..89927888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517287.4 → XP_011515589.1  oxidative stress-induced growth inhibitor 2 isoform X1

      See identical proteins and their annotated locations for XP_011515589.1

      UniProtKB/Swiss-Prot
      Q9Y236
      Conserved Domains (1) summary
      cl21454
      Location:173 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_011517288.4 → XP_011515590.1  oxidative stress-induced growth inhibitor 2 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:40 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      91025051..91051069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361178.1 → XP_054217153.1  oxidative stress-induced growth inhibitor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y236

    2. XM_054361179.1 → XP_054217154.1  oxidative stress-induced growth inhibitor 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y236.1 GenPept UniProtKB/Swiss-Prot:Q9Y236

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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