U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRSS38 serine protease 38 [ Homo sapiens (human) ]

    Gene ID: 339501, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PRSS38provided by HGNC
    Official Full Name
    serine protease 38provided by HGNC
    Primary source
    HGNC:HGNC:29625
    See related
    Ensembl:ENSG00000185888 AllianceGenome:HGNC:29625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPN2
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 1.8) See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PRSS38 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (227815675..227846470)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227004591..227035389)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228003376..228034171)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227928395-227928940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227928941-227929485 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:227929473-227929676 Neighboring gene synaptosome associated protein 47 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:227937705-227938206 Neighboring gene jumonji domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227949169-227949919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:227952921-227953670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227953671-227954420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227961766-227962583 Neighboring gene MPRA-validated peak747 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227965808-227966590 Neighboring gene uncharacterized LOC105373289 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227980229-227980892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:227981557-227982220 Neighboring gene MPRA-validated peak748 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228073527-228074122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228074123-228074719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228083643-228084489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228087252-228087752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228088986-228089986 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228101825-228101974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228102681-228103478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228103479-228104275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228107156-228108019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228108020-228108882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228114017-228114769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228117534-228118094 Neighboring gene negCOR silencer S7 Neighboring gene Wnt family member 9A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228129831-228130733 Neighboring gene uncharacterized LOC124904533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1903 Neighboring gene microRNA 5008

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    2. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Scholz CC, et al. PLoS Biol, 2016 Jan. PMID 26752685, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC163272

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine protease 38
    Names
    marapsin 2
    protease, serine 38
    serine protease MPN2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374657.2 → NP_001361586.1  serine protease 38 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL356323, AL731702
      Conserved Domains (1) summary
      cd00190
      Location:60 → 197
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_183062.3 → NP_898885.1  serine protease 38 isoform 1 precursor

      See identical proteins and their annotated locations for NP_898885.1

      Status: VALIDATED

      Source sequence(s)
      AL356323, AL731702
      Consensus CDS
      CCDS1563.1
      UniProtKB/Swiss-Prot
      A1L453, Q7RTY6
      Related
      ENSP00000355719.3, ENST00000366757.4
      Conserved Domains (1) summary
      cd00190
      Location:60 → 291
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      227815675..227846470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544175.3 → XP_011542477.1  serine protease 38 isoform X1

      Conserved Domains (2) summary
      smart00020
      Location:59 → 192
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:60 → 192
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227004591..227035389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336279.1 → XP_054192254.1  serine protease 38 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L453.2 GenPept UniProtKB/Swiss-Prot:A1L453

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools