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    MZT2B mitotic spindle organizing protein 2B [ Homo sapiens (human) ]

    Gene ID: 80097, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MZT2Bprovided by HGNC
    Official Full Name
    mitotic spindle organizing protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:25886
    See related
    Ensembl:ENSG00000152082 MIM:613450; AllianceGenome:HGNC:25886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM128B; MOZART2B
    Summary
    Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 10.8), colon (RPKM 10.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MZT2B in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130181654..130204793)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130616158..130638685)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130939835..130948300)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family member F Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:130886707-130887281 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16521 Neighboring gene coiled-coil domain containing 74B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130917957-130918586 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:130921824-130922007 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:130938087-130938883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130940784-130941520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130941521-130942257 Neighboring gene tubulin alpha 3e Neighboring gene ras homolog family member Q pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16524 Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex. Wieczorek M, et al. Cell Rep, 2020 Jun 30. PMID 32610146, Free PMC Article
    2. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Choi YK, et al. J Cell Biol, 2010 Dec 13. PMID 21135143, Free PMC Article
    3. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
    4. Proteomic profiling of Myc-associated proteins. Agrawal P, et al. Cell Cycle, 2010 Dec 15. PMID 21150319, Free PMC Article
    5. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. Feng K, et al. J Mol Cell Biol, 2021 Dec 30. PMID 34687317, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex.
      Title: MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14346, MGC87017

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic-spindle organizing protein 2B
    Names
    family with sequence similarity 128, member B
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330282.2 → NP_001317211.1  mitotic-spindle organizing protein 2B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018804
      Consensus CDS
      CCDS82511.1
      UniProtKB/TrEMBL
      B8ZZ87
      Related
      ENSP00000386419.1, ENST00000409255.1
      Conserved Domains (1) summary
      pfam12926
      Location:9 → 96
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    2. NM_001330284.2 → NP_001317213.1  mitotic-spindle organizing protein 2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC018804
      UniProtKB/TrEMBL
      H7C293
      Related
      ENSP00000404629.1, ENST00000455239.1
      Conserved Domains (1) summary
      pfam12926
      Location:9 → 57
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    3. NM_025029.5 → NP_079305.2  mitotic-spindle organizing protein 2B isoform 2

      See identical proteins and their annotated locations for NP_079305.2

      Status: VALIDATED

      Source sequence(s)
      AC018804, BC014255
      Consensus CDS
      CCDS2157.1
      UniProtKB/Swiss-Prot
      Q6NZ67, Q96CG4
      UniProtKB/TrEMBL
      A0A494C0V9
      Related
      ENSP00000281871.7, ENST00000281871.11
      Conserved Domains (1) summary
      pfam12926
      Location:9 → 96
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      130181654..130204793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445915.1 → XP_047301871.1  mitotic-spindle organizing protein 2B isoform X2

    2. XM_047445914.1 → XP_047301870.1  mitotic-spindle organizing protein 2B isoform X1

    3. XM_047445916.1 → XP_047301872.1  mitotic-spindle organizing protein 2B isoform X3

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791762.1 Reference GRCh38.p14 PATCHES

      Range
      358261..381343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332887.1 → XP_054188862.1  mitotic-spindle organizing protein 2B isoform X2

    2. XM_054332886.1 → XP_054188861.1  mitotic-spindle organizing protein 2B isoform X1

    3. XM_054332888.1 → XP_054188863.1  mitotic-spindle organizing protein 2B isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      130616158..130638685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344025.1 → XP_054200000.1  mitotic-spindle organizing protein 2B isoform X1

    2. XM_054344026.1 → XP_054200001.1  mitotic-spindle organizing protein 2B isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZ67.1 GenPept UniProtKB/Swiss-Prot:Q6NZ67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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