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    RAB24 RAB24, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 53917, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RAB24provided by HGNC
    Official Full Name
    RAB24, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9765
    See related
    Ensembl:ENSG00000169228 MIM:612415; AllianceGenome:HGNC:9765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
    Expression
    Ubiquitous expression in spleen (RPKM 20.5), appendix (RPKM 14.7) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See RAB24 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177301198..177303719, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177844433..177846953, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176728199..176730720, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176692158-176693050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176693051-176693942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:176696443-176697642 Neighboring gene ribosomal protein L21 pseudogene 60 Neighboring gene protein arginine methyltransferase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176722701-176723202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176723203-176723702 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176727388-176727581 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176728411-176729610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16677 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176730775-176731652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176737000-176737866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23705 Neighboring gene Sharpr-MPRA regulatory region 13731 Neighboring gene PRELI domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176746939-176747440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176747441-176747940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176751079-176751579 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:176753137-176754080 Neighboring gene MAX dimerization protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176763024-176763649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176765883-176766836 Neighboring gene lectin, mannose binding 2 Neighboring gene ribosomal protein S20 pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. Erdman RA, et al. J Biol Chem, 2000 Feb 11. PMID 10660536
    2. Mutant Rab24 GTPase is targeted to nuclear inclusions. Maltese WA, et al. BMC Cell Biol, 2002 Sep 25. PMID 12323076, Free PMC Article
    3. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Seitz S, et al. Nat Metab, 2019 Oct. PMID 32694843
    4. Rab24 is required for normal cell division. Militello RD, et al. Traffic, 2013 May. PMID 23387408
    5. Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation. Amaya C, et al. Traffic, 2016 Nov. PMID 27550070

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
      Title: Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
    2. Our work provides new insights into the molecular function of Rab24 in the last steps of the endosomal degradative pathway.
      Title: Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
    3. Rab24 modulates several mitotic events, including chromosome segregation and cytokinesis, perhaps through the interaction with microtubules
      Title: Rab24 is required for normal cell division.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: MXD3

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031677.4 → NP_001026847.1  ras-related protein Rab-24

      See identical proteins and their annotated locations for NP_001026847.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF087904, AI868941, AV698158, BC021263, DA898352
      Consensus CDS
      CCDS34300.1
      UniProtKB/Swiss-Prot
      A0A024R7N9, Q7Z4Z7, Q969Q5
      UniProtKB/TrEMBL
      F8W8H5
      Related
      ENSP00000304376.6, ENST00000303251.11
      Conserved Domains (1) summary
      cd04118
      Location:8 → 201
      Rab24; Rab GTPase family 24 (Rab24)

    2. NM_130781.4 → NP_570137.2  ras-related protein Rab-24

      See identical proteins and their annotated locations for NP_570137.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF087904, AI868941, AV698158, BC015534, DA898352
      Consensus CDS
      CCDS34300.1
      UniProtKB/Swiss-Prot
      A0A024R7N9, Q7Z4Z7, Q969Q5
      UniProtKB/TrEMBL
      F8W8H5
      Related
      ENSP00000377235.2, ENST00000393611.6
      Conserved Domains (1) summary
      cd04118
      Location:8 → 201
      Rab24; Rab GTPase family 24 (Rab24)

    RNA

    1. NR_109789.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 5' region, and includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF087904, AF258583, AI868941, AK308155, AV698158, DA898352

    2. NR_109790.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF087904, AF258583, AI868941, AV698158, DA058886
      Related
      ENST00000478234.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      177301198..177303719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      177844433..177846953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969Q5.1 GenPept UniProtKB/Swiss-Prot:Q969Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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