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    Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83521, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rradprovided by RGD
    Official Full Name
    RRAD, Ras related glycolysis inhibitor and calcium channel regulatorprovided by RGD
    Primary source
    RGD:69357
    See related
    Ensembl:ENSRNOG00000011901 AllianceGenome:RGD:69357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and calcium channel regulator activity. Involved in negative regulation of cell growth. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 894.3), Muscle (RPKM 95.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rrad in Genome Data Viewer
    Location:
    19p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (360581..363874)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (354184..357424)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (561696..564929)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 29, pseudogene 1 Neighboring gene cytosolic iron-sulfur assembly component 2B Neighboring gene cadherin 16 Neighboring gene uncharacterized LOC120098574 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ras associated with diabetes may play a role in fracture nonunion development in rats. Oda T, et al. BMC Musculoskelet Disord, 2019 Dec 12. PMID 31830958, Free PMC Article
    2. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Wang G, et al. Circ Res, 2010 Feb 5. PMID 19926875
    3. A novel Rad gene polymorphism combined with obesity increases risk for type 2 diabetes mellitus. Wang GY, et al. Chin Med J (Engl), 2004 May. PMID 15161552
    4. Analysis of trinucleotide-repeat combination polymorphism at the rad gene in patients with type 2 diabetes mellitus. Yuan X, et al. Metabolism, 1999 Feb. PMID 10024077
    5. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase. Sun Z, et al. Biochem Biophys Res Commun, 2011 May 27. PMID 21549102

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28
      Title: Ras associated with diabetes may play a role in fracture nonunion development in rats.
    2. Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
      Title: Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
    3. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts.
      Title: Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
    4. Rad-triggered apoptosis was mediated by the activation of p38 MAPK.
      Title: Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
    5. Results establish Rad as a novel endogenous regulator of cardiac EC coupling and betaAR signaling and support a parsimonious model in which Rad buffers Ca(v)beta to modulate LCC activity, EC coupling, and betaAR responsiveness.
      Title: Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
    6. Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway
      Title: Rad GTPase deficiency leads to cardiac hypertrophy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein RAD
    Names
    RAD1
    Ras-related associated with diabetes
    ras associated with diabetes
    NP_445790.2
    XP_006255117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053338.2 → NP_445790.2  GTP-binding protein RAD

      See identical proteins and their annotated locations for NP_445790.2

      Status: VALIDATED

      Source sequence(s)
      CK602305, CK840773, FM054321, FM055705
      UniProtKB/Swiss-Prot
      P55043
      UniProtKB/TrEMBL
      A6JXU5, G3V7K9
      Conserved Domains (2) summary
      cd04148
      Location:91 → 307
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
      smart00173
      Location:91 → 251
      RAS; Ras subfamily of RAS small GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      360581..363874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255055.5 → XP_006255117.1  GTP-binding protein RAD isoform X1

      See identical proteins and their annotated locations for XP_006255117.1

      UniProtKB/Swiss-Prot
      P55043
      UniProtKB/TrEMBL
      A6JXU5, G3V7K9
      Related
      ENSRNOP00000016259.2
      Conserved Domains (2) summary
      cd04148
      Location:91 → 307
      RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
      smart00173
      Location:91 → 251
      RAS; Ras subfamily of RAS small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55043.2 GenPept UniProtKB/Swiss-Prot:P55043

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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