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    Ctsc cathepsin C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25423, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ctscprovided by RGD
    Official Full Name
    cathepsin Cprovided by RGD
    Primary source
    RGD:2445
    See related
    EnsemblRapid:ENSRNOG00000016496 AllianceGenome:RGD:2445
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CATC; DPPI; DPP-I
    Summary
    Enables several functions, including chloride ion binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in positive regulation of proteolysis involved in protein catabolic process. Located in lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Liver (RPKM 604.8), Kidney (RPKM 269.7) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ctsc in Genome Data Viewer
    Location:
    1q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (151440860..151472430)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (142028386..142059841)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151918514..151949979)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 5 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 5 Neighboring gene uncharacterized LOC102554680 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB38, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dipeptidyl peptidase 1
    Names
    cathepsin J
    dipeptidyl peptidase I
    dipeptidyl transferase
    NP_058793.1
    XP_008757859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017097.2NP_058793.1  dipeptidyl peptidase 1 precursor

      See identical proteins and their annotated locations for NP_058793.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P80067, P80068
      UniProtKB/TrEMBL
      A6I5Z1
      Related
      ENSRNOP00000022342.3, ENSRNOT00000022342.7
      Conserved Domains (3) summary
      cd02621
      Location:230459
      Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
      cl28439
      Location:168204
      Pox_I6; Poxvirus I6-like family
      pfam08773
      Location:25138
      CathepsinC_exc; Cathepsin C exclusion domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      151440860..151472430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759637.4XP_008757859.1  dipeptidyl peptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_008757859.1

      UniProtKB/TrEMBL
      A0A8I5ZZG1, A0A8I6A0Q1, A6I5Z3
      Related
      ENSRNOP00000099158.1, ENSRNOT00000132158.1
      Conserved Domains (1) summary
      pfam08773
      Location:26106
      CathepsinC_exc; Cathepsin C exclusion domain