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    TRM2 tRNA (uracil(54)-C(5))-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRM2
    Official Full Name
    tRNA (uracil(54)-C(5))-methyltransferase
    Primary source
    SGD:S000001764
    Locus tag
    YKR056W
    See related
    AllianceGenome:SGD:S000001764; FungiDB:YKR056W; VEuPathDB:YKR056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NUC2; NUD1; RNC1
    Summary
    Enables double-stranded DNA 5'-3' exodeoxyribonuclease activity; single-stranded DNA endodeoxyribonuclease activity; and tRNA (m5U54) methyltransferase activity. Involved in tRNA modification. Orthologous to several human genes including TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TRM2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (549448..551367)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene dynein heavy chain Neighboring gene Rho family GTPase RHO4 Neighboring gene ribosomal 40S subunit protein S21A Neighboring gene glycogenin glucosyltransferase GLG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation. Johansson MJ, et al. RNA, 2002 Mar. PMID 12003492, Free PMC Article
    2. Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae. Nordlund ME, et al. RNA, 2000 Jun. PMID 10864043, Free PMC Article
    3. Over-expression of the NUD1-coded endo-exonuclease in Saccharomyces cerevisiae enhances DNA recombination and repair. Sadekova S, et al. Curr Genet, 1996 Jun. PMID 8662209
    4. In-vitro recombination in rad and rnc mutants of Saccharomyces cerevisiae. Moore PD, et al. Curr Genet, 1993 Jan. PMID 8428378
    5. Defects in modification of cytoplasmic and mitochondrial transfer RNAs are caused by single nuclear mutations. Hopper AK, et al. Cell, 1982 Mar. PMID 7074684

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A defective processing in absence of TRM2, with a synergistic effect of TRM2, and EXO1 in such DNA repair processing.
      Title: Synergistic effect of TRM2/RNC1 and EXO1 in DNA double-strand break repair in Saccharomyces cerevisiae.
    2. These results propose an important role for TRM2 in DNA repair with a potential involvement of its nuclease function in homologous recombination based repair of DNA double strand break.
      Title: Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA 5'-3' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (uracil(54)-C(5))-methyltransferase
    NP_012982.2
    • tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; endo-exonuclease with a role in DNA repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      549448..551367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179846.1 → NP_012982.2  TPA: tRNA (uracil(54)-C(5))-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012982.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB7, P33753, Q86ZR6, Q9HGQ5
      UniProtKB/TrEMBL
      B5VMK5
      Conserved Domains (1) summary
      COG2265
      Location:166 → 632
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33753.2

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