RN7SK RNA component of 7SK nuclear ribonucleoprotein [Homo sapiens (human)] - Gene

Summary

Official Symbol: RN7SKprovided by HGNC
Official Full Name: RNA component of 7SK nuclear ribonucleoproteinprovided by HGNC
Primary source: HGNC:HGNC:10037
See related: Ensembl:ENSG00000202198 MIM:606515; AllianceGenome:HGNC:10037
Gene type: snRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 7SK
Summary: Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

Location:: 6p12.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (52995620..52995951)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (52835189..52835520)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (52860418..52860749)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line.
Title: 7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line.
A positive feedback circuit between RN7SK snRNA and m[6]A readers is essential for tumorigenesis.
Title: A positive feedback circuit between RN7SK snRNA and m(6)A readers is essential for tumorigenesis.
RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin.
Title: RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin.
[7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6].
Title: [7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6].
Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex.
Title: Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex.
Our results demonstrated the transient knockdown of Rn7SK in mesenchymal stem cells leads to delayed senescence, while its overexpressions shows opposite effects.
Title: Rn7SK small nuclear RNA is involved in cellular senescence.
The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes.
Title: 7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features.
These findings identify a novel role for HIV-1 TAR in the absence of Tat, involving the interference with host cellular immune responses by targeting 7SK RNA-mediated gene expression and P-TEFb inactivation.
Title: Latent HIV-1 TAR Regulates 7SK-responsive P-TEFb Target Genes and Targets Cellular Immune Responses in the Absence of Tat.
The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.
Title: The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.
7SK expression is significantly down-regulated in cancer.7SK transcriptional level decreased in stem cells in comparison with differentiated cell types.
Title: 7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

7SK small nuclear RNA
RNA, 7SK small nuclear
RNA, 7SK, nuclear

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in negative regulation of transcription elongation by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of 7SK snRNP	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.