Fyb1 FYN binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fyb1provided by MGI
Official Full Name: FYN binding protein 1provided by MGI
Primary source: MGI:MGI:1346327
See related: Ensembl:ENSMUSG00000022148 AllianceGenome:MGI:1346327
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fyb; ADAP; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik
Summary: The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Expression: Biased expression in thymus adult (RPKM 13.6), spleen adult (RPKM 5.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.19 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (6552280..6695089)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (6522796..6665608)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia.
Title: ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia.
Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function.
Title: Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function.
ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Title: ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Results demonstrated that loss of ADAP restricted to the megakaryocytic lineage, has no impact on other hematopoietic cells, causes thrombocytopenia and reduced plasma levels of PF4 and TGF-beta1, impairs CLEC-2-mediated platelet activation in vitro, and results in enhanced experimental autoimmune encephalomyelitis severity.
Title: Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP.
Adap(-/-) mice have moderate thrombocytopenia and smaller platelets. Adap(-/-) platelets had a shorter life span than controlss. Cultured ADAP(-) BM-derived MKs had reduced spreading on extracellular matrix proteins and beta1 integrin activation, impaired podosome formation, and defective polarization of the demarcation membrane system. ADAP has an unspecified role in the process of MK polarization and platelet biogene...
Title: ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
ADAP fulfills different functions in CD4(+) and CD8(+) T cells, with CD8(+) T cells being less dependent on ADAP.
Title: ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
ADAP regulates CD8 T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues.
Title: Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 production and TGFbeta1-induced CD103 expression in CD8+ T-lymphocytes and protects against influenza H5N1 virus infection.
Title: The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
The results indicate that ADAP dampens naive CD8 T cell responses to lymphopenia and IL-15, and they demonstrate a novel Ag-independent function for ADAP in the suppression of memory phenotype CD8 T cell generation.
Title: Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively.
Title: TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224554

PMC152247P1 (e-PCR)
- UniSTS:271206

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: FYN-binding protein 1

Names: FYN binding protein FYB-130; FYN-T-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation promoting adaptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278269.1 → NP_001265198.1 FYN-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001265198.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AC158901, AC161196, AK137907

UniProtKB/Swiss-Prot

O35601

Conserved Domains (2) summary

pfam14603
Location:691 → 773

hSH3; Helically-extended SH3 domain

cl17036
Location:496 → 591

SH3; Src Homology 3 domain superfamily
NM_011815.5 → NP_035945.1 FYN-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_035945.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC158901, AC161196

Consensus CDS

CCDS37031.1

UniProtKB/Swiss-Prot

O35601, Q9Z2H3

UniProtKB/TrEMBL

B2RUR0

Related

ENSMUSP00000087947.6, ENSMUST00000090461.12

Conserved Domains (2) summary

pfam14603
Location:737 → 819

hSH3; Helically-extended SH3 domain

cl17036
Location:496 → 591

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

6552280..6695089

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245328.3 → XP_011243630.1 FYN-binding protein 1 isoform X1

Conserved Domains (2) summary

pfam07653
Location:513 → 568

SH3_2; Variant SH3 domain

pfam14603
Location:750 → 837

hSH3; Helically-extended SH3 domain
XM_011245329.3 → XP_011243631.1 FYN-binding protein 1 isoform X4

Conserved Domains (2) summary

pfam07653
Location:513 → 568

SH3_2; Variant SH3 domain

pfam14603
Location:704 → 791

hSH3; Helically-extended SH3 domain
XM_006519982.2 → XP_006520045.1 FYN-binding protein 1 isoform X2

Conserved Domains (2) summary

pfam07653
Location:513 → 568

SH3_2; Variant SH3 domain

pfam14603
Location:742 → 829

hSH3; Helically-extended SH3 domain
XM_006519985.2 → XP_006520048.1 FYN-binding protein 1 isoform X5

Conserved Domains (2) summary

pfam07653
Location:513 → 568

SH3_2; Variant SH3 domain

pfam14603
Location:696 → 783

hSH3; Helically-extended SH3 domain
XM_036159389.1 → XP_036015282.1 FYN-binding protein 1 isoform X6

Conserved Domains (1) summary

cl17036
Location:506 → 601

SH3; Src Homology 3 domain superfamily
XM_006519983.4 → XP_006520046.1 FYN-binding protein 1 isoform X3

Conserved Domains (2) summary

pfam07653
Location:503 → 558

SH3_2; Variant SH3 domain

pfam14603
Location:740 → 827

hSH3; Helically-extended SH3 domain
XM_006519986.1 → XP_006520049.1 FYN-binding protein 1 isoform X7

Conserved Domains (2) summary

pfam07653
Location:73 → 128

SH3_2; Variant SH3 domain

pfam14603
Location:310 → 397

hSH3; Helically-extended SH3 domain