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    Cdkn2b cyclin dependent kinase inhibitor 2B [ Mus musculus (house mouse) ]

    Gene ID: 12579, updated on 28-Oct-2024

    Summary

    Official Symbol
    Cdkn2bprovided by MGI
    Official Full Name
    cyclin dependent kinase inhibitor 2Bprovided by MGI
    Primary source
    MGI:MGI:104737
    See related
    Ensembl:ENSMUSG00000073802 AllianceGenome:MGI:104737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p15; MTS2; INK4b; p15INK4b; p15(INK4b)
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and liver. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in small intestine adult (RPKM 85.1), colon adult (RPKM 73.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdkn2b in Genome Data Viewer
    Location:
    4 C4; 4 42.15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (89224526..89229269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (89306289..89311032, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene TGFB-induced factor homeobox 2, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_10736 Neighboring gene STARR-seq mESC enhancer starr_10737 Neighboring gene STARR-positive B cell enhancer ABC_E1646 Neighboring gene cyclin dependent kinase inhibitor 2A Neighboring gene STARR-seq mESC enhancer starr_10738 Neighboring gene STARR-positive B cell enhancer ABC_E11246 Neighboring gene predicted gene 12610 Neighboring gene STARR-seq mESC enhancer starr_10739 Neighboring gene STARR-seq mESC enhancer starr_10740 Neighboring gene VISTA enhancer mm10 Neighboring gene STARR-seq mESC enhancer starr_10741 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 8 Neighboring gene predicted gene, 54238

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in megakaryocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G0 to G1 transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spleen development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 4 inhibitor B
    Names
    cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
    cyclin-dependent kinase inhibitor p15
    cyclin-dependent kinase inhibitor p15INK4b
    cyclin-dependent kinase inhibitor protein
    p14-INK4b
    p15-INK4b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007670.4NP_031696.1  cyclin-dependent kinase 4 inhibitor B

      See identical proteins and their annotated locations for NP_031696.1

      Status: VALIDATED

      Source sequence(s)
      AF059567, CAAA01036593, DT919921
      Consensus CDS
      CCDS18351.1
      UniProtKB/Swiss-Prot
      P55271
      UniProtKB/TrEMBL
      Q3UNM8, Q549R4
      Related
      ENSMUSP00000095595.5, ENSMUST00000097981.6
      Conserved Domains (3) summary
      cd00204
      Location:13124
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:10102
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1036
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      89224526..89229269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)