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    RNF146 ring finger protein 146 [ Homo sapiens (human) ]

    Gene ID: 81847, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RNF146provided by HGNC
    Official Full Name
    ring finger protein 146provided by HGNC
    Primary source
    HGNC:HGNC:21336
    See related
    Ensembl:ENSG00000118518 MIM:612137; AllianceGenome:HGNC:21336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF146 in Genome Data Viewer
    Location:
    6q22.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127266682..127288562)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128455637..128477520)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127587827..127609707)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377989 Neighboring gene R-spondin 3 Neighboring gene uncharacterized LOC124901398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17528 Neighboring gene uncharacterized LOC105377994 Neighboring gene ethylmalonyl-CoA decarboxylase 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:127653558-127654108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:127654109-127654658 Neighboring gene RNA, 5S ribosomal pseudogene 217 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:127664039-127664912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:127665787-127666660 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Wang Z, et al. Genes Dev, 2012 Feb 1. PMID 22267412, Free PMC Article
    2. Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase. Zhou ZD, et al. Cell Adh Migr, 2011 Nov-Dec. PMID 22274711, Free PMC Article
    3. Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway. Gao Y, et al. PLoS One, 2014. PMID 24454854, Free PMC Article
    4. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke. Belayev L, et al. Cell Death Differ, 2017 Jun. PMID 28430183, Free PMC Article
    5. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. von Rotz RC, et al. Eur J Neurosci, 2005 Mar. PMID 15813938

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/beta-catenin signaling to promote the progression of hepatocellular carcinoma.
      Title: SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.
    2. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
      Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
    3. Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
      Title: Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
    4. Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
      Title: Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
    5. Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression.
      Title: Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
    6. RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
      Title: The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1.
    7. Iduna expression under disruptive neurohomeostasis (e.g., uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival, halting neural cell death.
      Title: Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.
    8. the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell
      Title: Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
    9. RNF146 regulated the development and progression of NSCLC
      Title: Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
    10. Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.
      Title: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants at 6q22 and 17q21 are associated with intracranial volume.
    EBI GWAS Catalog
    Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • dJ351K20.1, 2610509H23Rik, DKFZp434O1427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables poly-ADP-D-ribose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly-ADP-D-ribose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein K48-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF146
    Names
    RING-type E3 ubiquitin transferase RNF146
    dactylidin
    iduna
    NP_001229773.1
    NP_001229774.1
    NP_001229775.1
    NP_001229776.1
    NP_001229777.1
    NP_001229778.1
    NP_001229779.1
    NP_001229780.1
    NP_001229781.1
    NP_112225.2
    XP_011534463.1
    XP_011534465.1
    XP_011534466.1
    XP_016866825.1
    XP_047275342.1
    XP_047275343.1
    XP_047275344.1
    XP_047275345.1
    XP_054212474.1
    XP_054212475.1
    XP_054212476.1
    XP_054212477.1
    XP_054212478.1
    XP_054212479.1
    XP_054212480.1
    XP_054212481.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242844.2 → NP_001229773.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, DA639989
      Consensus CDS
      CCDS5136.1
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    2. NM_001242845.2 → NP_001229774.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, BI669435, DA707096, DB267873
      Consensus CDS
      CCDS5136.1
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    3. NM_001242846.2 → NP_001229775.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, DA043259, DB267873
      Consensus CDS
      CCDS5136.1
      UniProtKB/Swiss-Prot
      Q9NTX7
      Related
      ENSP00000477168.1, ENST00000608991.5
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    4. NM_001242847.2 → NP_001229776.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, DA707096
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    5. NM_001242848.2 → NP_001229777.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, DA145911
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    6. NM_001242849.2 → NP_001229778.1  E3 ubiquitin-protein ligase RNF146 isoform b

      See identical proteins and their annotated locations for NP_001229778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
      Source sequence(s)
      AI929027, AJ420549, CN388414
      Consensus CDS
      CCDS56449.1
      UniProtKB/Swiss-Prot
      E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
      Related
      ENSP00000476814.1, ENST00000610153.1
      Conserved Domains (2) summary
      smart00678
      Location:104 → 176
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:36 → 75
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    7. NM_001242850.2 → NP_001229779.1  E3 ubiquitin-protein ligase RNF146 isoform b

      See identical proteins and their annotated locations for NP_001229779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
      Source sequence(s)
      AJ420549, AK027558
      Consensus CDS
      CCDS56449.1
      UniProtKB/Swiss-Prot
      E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
      Related
      ENSP00000357297.1, ENST00000368314.6
      Conserved Domains (2) summary
      smart00678
      Location:104 → 176
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:36 → 75
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    8. NM_001242851.1 → NP_001229780.1  E3 ubiquitin-protein ligase RNF146 isoform b

      See identical proteins and their annotated locations for NP_001229780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains an alternate 5' terminal exon and lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
      Source sequence(s)
      AJ420549, BG708628, BI771613
      Consensus CDS
      CCDS56449.1
      UniProtKB/Swiss-Prot
      E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:104 → 176
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:36 → 75
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    9. NM_001242852.2 → NP_001229781.1  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_001229781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-4 and variant 7 encode the same isoform.
      Source sequence(s)
      AI929027, AJ420549, AL136829, DA826982
      Consensus CDS
      CCDS5136.1
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    10. NM_030963.4 → NP_112225.2  E3 ubiquitin-protein ligase RNF146 isoform a

      See identical proteins and their annotated locations for NP_112225.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
      Source sequence(s)
      AJ420549, AL136829, DB267873
      Consensus CDS
      CCDS5136.1
      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      127266682..127288562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011336.3 → XP_016866825.1  E3 ubiquitin-protein ligase RNF146 isoform X1

      UniProtKB/Swiss-Prot
      E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:104 → 176
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:36 → 75
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    2. XM_047419389.1 → XP_047275345.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    3. XM_047419386.1 → XP_047275342.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    4. XM_047419388.1 → XP_047275344.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    5. XM_011536161.4 → XP_011534463.1  E3 ubiquitin-protein ligase RNF146 isoform X2

      See identical proteins and their annotated locations for XP_011534463.1

      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    6. XM_011536163.4 → XP_011534465.1  E3 ubiquitin-protein ligase RNF146 isoform X2

      See identical proteins and their annotated locations for XP_011534465.1

      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    7. XM_011536164.4 → XP_011534466.1  E3 ubiquitin-protein ligase RNF146 isoform X2

      See identical proteins and their annotated locations for XP_011534466.1

      UniProtKB/Swiss-Prot
      Q9NTX7
      Conserved Domains (2) summary
      smart00678
      Location:103 → 175
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16546
      Location:35 → 74
      RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

    8. XM_047419387.1 → XP_047275343.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      128455637..128477520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356499.1 → XP_054212474.1  E3 ubiquitin-protein ligase RNF146 isoform X1

      UniProtKB/Swiss-Prot
      E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

    2. XM_054356503.1 → XP_054212478.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    3. XM_054356500.1 → XP_054212475.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    4. XM_054356502.1 → XP_054212477.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    5. XM_054356504.1 → XP_054212479.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    6. XM_054356505.1 → XP_054212480.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    7. XM_054356506.1 → XP_054212481.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    8. XM_054356501.1 → XP_054212476.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NTX7.1 GenPept UniProtKB/Swiss-Prot:Q9NTX7

    Gene LinkOut

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