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    TNFAIP2 TNF alpha induced protein 2 [ Homo sapiens (human) ]

    Gene ID: 7127, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TNFAIP2provided by HGNC
    Official Full Name
    TNF alpha induced protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11895
    See related
    Ensembl:ENSG00000185215 MIM:603300; AllianceGenome:HGNC:11895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B94; EXOC3L3
    Summary
    This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNFAIP2 in Genome Data Viewer
    Location:
    14q32.32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103121469..103137439)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97357363..97373355)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103589798..103603776)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103559931-103560500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103561071-103561640 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103564684-103564853 Neighboring gene exocyst complex component 3 like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103570895-103571645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103576032-103576642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103576643-103577253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103588729-103589261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103589262-103589795 Neighboring gene long intergenic non-protein coding RNA 677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103594547-103595312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103598606-103599176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103599177-103599745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103601649-103602150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9098 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 11 Neighboring gene ribosomal protein L21 pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma. Zhang J, et al. PLoS One, 2014. PMID 25383966, Free PMC Article
    2. The roles of TNFAIP2 in cancers and infectious diseases. Jia L, et al. J Cell Mol Med, 2018 Nov. PMID 30145807, Free PMC Article
    3. TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells. Niwa N, et al. Lab Invest, 2019 Nov. PMID 31263157
    4. Translation of TNFAIP2 is tightly controlled by upstream open reading frames. Scholz A, et al. Cell Mol Life Sci, 2020 May. PMID 31392347, Free PMC Article
    5. Downregulation of TNFAIP2 suppresses proliferation and metastasis in esophageal squamous cell carcinoma through activation of the Wnt/β-catenin signaling pathway. Xie Y, et al. Oncol Rep, 2017 May. PMID 28393234

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in acute myeloid leukaemia.
      Title: The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in acute myeloid leukaemia.
    2. TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
      Title: TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
    3. Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
      Title: Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
    4. STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
      Title: STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
    5. M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
      Title: M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
    6. Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
      Title: Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
    7. Knockdown of TNFAIP2 resulted in upregulation of E-cadherin expression and downregulation of TWIST1 expression, which decreased motile function in platinum-resistant urothelial cancer cells.
      Title: TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.
    8. we establish TNFAIP2 as a novel target of uORF-mediated translational regulation. Furthermore, our findings suggest that during macrophage differentiation a major uORF-dependent translational switch occurs.
      Title: Translation of TNFAIP2 is tightly controlled by upstream open reading frames.
    9. ERp29-MSec interaction appeared to require the presence of other bridging protein(s), perhaps triggered by post-translational modification of ERp29
      Title: The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.
    10. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
      Title: The roles of TNFAIP2 in cancers and infectious diseases.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 2
    Names
    exocyst complex component 3-like 3
    primary response gene B94 protein
    tumor necrosis factor, alpha induced protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371220.1 → NP_001358149.1  tumor necrosis factor alpha-induced protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161669
      Related
      ENSP00000452914.2, ENST00000559255.2
      Conserved Domains (1) summary
      pfam06046
      Location:122 → 651
      Sec6; Exocyst complex component Sec6

    2. NM_001371221.1 → NP_001358150.1  tumor necrosis factor alpha-induced protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161669
      Conserved Domains (1) summary
      pfam06046
      Location:122 → 651
      Sec6; Exocyst complex component Sec6

    3. NM_006291.4 → NP_006282.2  tumor necrosis factor alpha-induced protein 2 isoform 1

      See identical proteins and their annotated locations for NP_006282.2

      Status: REVIEWED

      Source sequence(s)
      AL161669
      Consensus CDS
      CCDS9979.1
      UniProtKB/Swiss-Prot
      Q03169, Q86VI0
      Related
      ENSP00000452634.2, ENST00000560869.6
      Conserved Domains (1) summary
      pfam06046
      Location:122 → 651
      Sec6; Exocyst complex component Sec6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103121469..103137439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431737.1 → XP_047287693.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    2. XM_011537113.3 → XP_011535415.1  tumor necrosis factor alpha-induced protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011535415.1

      Conserved Domains (1) summary
      pfam06046
      Location:122 → 651
      Sec6; Exocyst complex component Sec6

    3. XM_047431736.1 → XP_047287692.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    4. XM_011537112.3 → XP_011535414.1  tumor necrosis factor alpha-induced protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011535414.1

      Conserved Domains (1) summary
      pfam06046
      Location:122 → 651
      Sec6; Exocyst complex component Sec6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97357363..97373355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376662.1 → XP_054232637.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    2. XM_054376658.1 → XP_054232633.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    3. XM_054376661.1 → XP_054232636.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    4. XM_054376659.1 → XP_054232634.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    5. XM_054376660.1 → XP_054232635.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03169.2 GenPept UniProtKB/Swiss-Prot:Q03169

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