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    FILNC1 FOXO induced long non-coding RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100132735, updated on 17-Jun-2024

    Summary

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    Official Symbol
    FILNC1provided by HGNC
    Official Full Name
    FOXO induced long non-coding RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:53755
    See related
    Ensembl:ENSG00000231426 AllianceGenome:HGNC:53755
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants. [provided by RefSeq, Oct 2017]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See FILNC1 in Genome Data Viewer
    Location:
    6q24.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139771073..139860471)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140954833..141044210)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (140092210..140181608)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.4971 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:139961222-139961389 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17613 Neighboring gene CRISPRi-validated cis-regulatory element chr6.4973 Neighboring gene thyroid hormone receptor interactor 4 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:140091503-140091680 Neighboring gene NANOG hESC enhancer GRCh37_chr6:140205336-140205876 Neighboring gene VISTA enhancer hs1644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25173 Neighboring gene Sharpr-MPRA regulatory region 3903 Neighboring gene uncharacterized LOC103352541 Neighboring gene Sharpr-MPRA regulatory region 1100 Neighboring gene long intergenic non-protein coding RNA 2941 Neighboring gene uncharacterized LOC107986652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Xiao ZD, et al. Nat Commun, 2017 Oct 4. PMID 28978906, Free PMC Article
    2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. PLoS Genet, 2013. PMID 23382691, Free PMC Article
    3. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038399.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL050338, BM905115
      Related
      ENST00000647420.1

    2. NR_138541.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL050338, BM788274

    3. NR_138542.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA058905, AL050338, BM788274

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      139771073..139860471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      140954833..141044210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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