ROR1-AS1 ROR1 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ROR1-AS1provided by HGNC
Official Full Name: ROR1 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:40508
See related: Ensembl:ENSG00000223949 AllianceGenome:HGNC:40508
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Restricted expression toward testis (RPKM 1.4) See more
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Genomic context

Location:: 1p31.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (64094442..64113791, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (63970220..63989553, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (64560125..64579474, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis.
Title: Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis.
ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
Title: ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
Title: Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
Title: ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
Title: LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
Results suggested that ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC.
Title: Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375.
Data found that expression of lncRNA ROR1AS1 was significantly increased in hepatocellular carcinoma (HCC) patients and associated with several clinical features and an undesirable prognosis; therefore, lncRNA ROR1AS1 may serve as a useful biomarker for the prognosis of patients with HCC.
Title: LncRNA ROR1‑AS1 high expression and its prognostic significance in liver cancer.
ROR1-AS1 directly bound with miR-504 and act as a molecular sponge to decrease miR-504 expression. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis.
Title: Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_110665.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AK096291, AL445205
NR_110666.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' and 3' structure and is shorter compared to variant 1.

Source sequence(s)

AL445205, BC040909

Related

ENST00000412349.7